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《Journal of Zhengzhou University(Medical Sciences)》 2015-01
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Analysis of genetic polymorphism of multi-copy Y-STR marker DYF399S1 among Han population in Henan Province

ZHANG Jing;WANG Lei;HUANG Yanmei;MA Yalei;SHANG Wanbing;ZHANG Yinke;GUO Dong;HUANG Shuqin;Department of Forensic Genetics,Xinxiang Medical University;Forensic Science and Technology Institute,Zhengzhou Public Security Bureau;  
Aim: To investigate the genetic polymorphism of a new multi-copy locus DYF399S1 on Y chromosome among Han population in Henan Province.Methods: The products amplified using fluorescent-PCR from 248 unrelated Henan Han males were separated and the allelic fragments were sequenced on ABI 3130 genetic analyzer.Results:DYF399S1 was a three-copies locus.The core sequence was GAAA and the alleles were from 12 to 22.The motif of DYF399S1 locus included 1 stable and 1 variant repeat structure,namely,( GAAA)3N7( GAAA)12-22.A total of 94 haplotypes were identified among 248 unrelated men from Henan Han populations.Out of them,the most frequent haplotype was18 /18 /18 and the frequency was 0.080 6; 49 types were observed once only and the frequency was 0.004 0.The discrimination capacity( DC) was 0.372 5,and the haplotype diversity and the discriminating power were 0.865 5 and 0.862 1,respectively.Conclusion: DYF399S1 locus is a highly polymorphic marker and useful for applying to forensic medicine and human evolution study.
【Fund】: 河南省教育厅自然科学基金资助项目13A310849;; 新乡医学院培育基金重点项目2013ZD114;; 新乡医学院大学生科研课题DX-SKYKT2012-015
【CateGory Index】: D919.4
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【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 ZHU Chuan-hong;ZHOU Xiang;SHAO Yi;Department of Criminal Police,Public Security Bureau of Wuhan;;Study on genetic polymorphism and mutation of 24 Y-STR loci for Han population in Hubei[J];Forensic Science and Technology;2014-01
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