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Studies on the mechanism of chroaic restraint stress induced gastric mucosa cytoprotection in rats

XU Ji-tian;LI Lei;LIU Jian-zhong; et al (Department of Physiology, Henan Medical University, Zhengzhou 450052, China)  
s Objective: To study the effect of chronic stress on the ethanol induced gastric mucosa damage and analysis the peripheric mechanism. Methods: Chronic restraint stress (CRS) was carried out and the mode of gastric mucosa damage was made by intragastric 70% ethanol in at. Results: ①The gastric mucosa damage by ethanol was significant attenuated af- ter the rats had receivsed CRS for 4 or 7 days. The protection of CRS was not affected in rats with Vagotomy but disappareds in sympathectomized rats. ② Adminitration of isoprenaline or dopamine before CRS could partially, and norepinephrine could not, restore the protection sin sympathectomized rats. In rats with intact sympathetic nerve, preinjection of haoperidel or propranolol inhibited CBS induced protection which, however, was not affected by phentalamine. ③The level of plasma gastrin was decreased in both nomal and sympathectomized rats after CRS. But the plasma somatostain was not changed. CRS also promote thse secretion of gastric mucus. But there is no effect on the secretion of gastric juice and gastric acid. Conclusion : The aetivation of sympathetic nervous system mediated the adaptive cytoprotection of gastric mucosa in CRS tats and the effect are probably mediated through β and doparminhe receptors. The increase of gastric mucus secretion is also possibly one of the mechanism osf protect gastric mucosa of CRS.
【Fund】: 河南省医学科学院科研基金
【CateGory Index】: R333
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