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THE EFFECTS OF GYPENOSIDE ON EXPERIMENTAL HYPERLIPIDEMIA IN RATS

Han Xiaoyan; Wei Hong-bo; Lian Jan-xue et al(Department of pharmacology,Medical College,LouYang 471003)  
After the rats with hyperlipidemia were orally treated with the gypenoside(150mg/kg·d)for 12 weaks the blood levels of TC and TG were significantly decreased,and the con-centration of HDL was greatly increased.The contents of TC in the rats liver and aortic wall werealso significantly decreased.It was also found that the concentration of LPO in serums and liversof the rats with hyperlipidemia was markedly reduced by gypenoside,but the activity of SOD waselevated.From results obtained,it is suggested gypenoside possessed the therapeutic on hyperlipi-demia together with hepaticdernage and atherosclerosis.
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