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《Journal of Hainan Medical University》 2010-06
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Influence of appetite promotion decoction on the mucosal healing and EGF expression in gastric ulcer model mice

ZHANG Zhi-yong1,SUN Gong-kai2,YANG Shi-zhong2 (Affiliated Hospital of Hainan Medical University,Haikou 570102,China)  
Objective: To explore the influences of appetite promotion decoction on the mucosal healing and EGF expression in gastric ulcer model of mice,and its mechanism.Methods: Gastric ulcer model of mice were induced by subserosal injection of glacial acetic acid and then randomly divided into normal saline group(B),ranitidine group(C),appetite promotion decoction group(D),and normal control group(A).Ulcer index was measured with vernier caliper,and EGF expression in the mucosa tissue was evaluated by immune-histochemical method.Results: Significantly different size of UI and level of EGF repression were presented when group C and D were compared with group B,group D was compared with group C(P 0.05 or 0.01).Besides,EGF expression level in the adjacent tissues of gastric ulcer lesion of group C and D gradually increased comparing with that of group A and B,showing significant differences(P0.01).Conclusions: Appetite promotion decoction can promote EGF secretion,protect epithelial cells of gastric mucous,and facilitate the recovery of gastric ulcer by accelerating the proliferation,differentiation,migration,and tissue repair.
【Fund】: 海南医学院科研基金资助学报项目(0020100190)~~
【CateGory Index】: R285.5
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