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《Journal of Hainan Medical University》 2010-06
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Influence of appetite promotion decoction on the mucosal healing and EGF expression in gastric ulcer model mice

ZHANG Zhi-yong1,SUN Gong-kai2,YANG Shi-zhong2 (Affiliated Hospital of Hainan Medical University,Haikou 570102,China)  
Objective: To explore the influences of appetite promotion decoction on the mucosal healing and EGF expression in gastric ulcer model of mice,and its mechanism.Methods: Gastric ulcer model of mice were induced by subserosal injection of glacial acetic acid and then randomly divided into normal saline group(B),ranitidine group(C),appetite promotion decoction group(D),and normal control group(A).Ulcer index was measured with vernier caliper,and EGF expression in the mucosa tissue was evaluated by immune-histochemical method.Results: Significantly different size of UI and level of EGF repression were presented when group C and D were compared with group B,group D was compared with group C(P 0.05 or 0.01).Besides,EGF expression level in the adjacent tissues of gastric ulcer lesion of group C and D gradually increased comparing with that of group A and B,showing significant differences(P0.01).Conclusions: Appetite promotion decoction can promote EGF secretion,protect epithelial cells of gastric mucous,and facilitate the recovery of gastric ulcer by accelerating the proliferation,differentiation,migration,and tissue repair.
【Fund】: 海南医学院科研基金资助学报项目(0020100190)~~
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Xuesong; LI Yinong; YE Simao; DONG Xiuyun(Department of Gastroenterology, The Third Hospital,Beijing Medical University 100083);EXPERIMENTAL STUDY OF CORRELATION OF GASTRIC ULCER HEALING QUALITY WITH RISISTANCE TO REINJURY BY PREDNISONE IN RATS[J];Journal of Beijing Medical University;1996-06
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 LIU Jian-ping HU Dong-ju(Hospital of Traditional Chinese Medicine in Hebei Province,Shijiazhuang 050011);Study of Effect of Weixikang Apozema on Growth Factor of Acetic Acid Gastric Ulcer Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
2 XIE Hui-chen(Department of medicine,Hubei Institute for Nationalities,Enshi 445000,China);Jiajianbamxiaxiexin Decoction Treat the Rat with Peptic Ulcer[J];Journal of Hubei Institute for Nationalities(Medical Edition);2006-01
3 Lin Shouning Ruikang Affiliated Hospital,Guangxi TCMUniversity,530011 Huang Guihua Wei Wei Guangxi TCMUniversity,530001;Effects of AnWeiTang Granule on Serum Gastrin and Epidemic Growth Factor in Experimental Rats with Gastric Ulcer[J];Guangxi Journal of Traditional Chinese Medicine;2005-05
4 WEI Wei,LIN Shou-ning,HUANG Gui-hua,TENG Jiu-xiang(TCM University of Hunan,Changsha,Hunan 410007,China);Effects of Anwei decoction on EGF of gastric ulcer in rats[J];Journal of Traditional Chinese Medicine University of Hunan;2008-06
5 HUANG Shi,LIN Shou-ning,ZHU Yong-ping (Department of Gastroenteroliogy,Rui Kang Hospital,Guangxi College of TCM,Nanning 530011,Guangxi,China);Clinical Observation on Treating Gastric Ulcer with TCM and WM Combined[J];Liaoning Journal of Traditional Chinese Medicine;2003-11
6 HUANG Gui-hua1,LIN Shou-ning1,WEI Wei2(1.Guangxi University of TCM,Nanning 530001,Guangxi,China;2.Digestion Department,Ruikang Affiliated Hospital of Guangxi University of TCM,Nanning 530001,Guangxi,China);Effects of Anweitang Granule on the EGF and EGFR Expression in Gastric Mucosa of Experimental Rats[J];Liaoning Journal of Traditional Chinese Medicine;2005-10
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Men Zirong Qian Dongmei Liu Fuqiang Yang Min Wan Xiaoping Wang Yan Yuan Shenyuan Di Xia Xie Xinji (Beijing Tong Ren hospital,Beijing 100730);Determination of T lymphocyte Subpopulation in Peripheral Blood from Patients with Different Gastric Diseases[J];BASIC MEDICAL SCIENCES AND CLINICS;1998-03
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