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《Journal of Hainan Medical University》 2010-07
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Effect of Xiyanping on herpangina in children

TAN Xiao-hong,CHEN Bao-chuan(Quanzhou Children's Hospital,Quanzhou 362000,China)  
Objective:To observe the effects of Xiyanping injection on the immune function in children with herpangina.Methods:Randomly divided 389 eligible children with herpangina into two groups treated with Xiyanping and ribavirin,respectively.Observed the disappearance time of ever and herpes of the two groups.Besides,evaluated immune function indicators including CD4+,CD8+,CD4+/CD8+,IFN-γ,IL-10 before and after the treatment.Results:For those patients,CD4+,CD4+/CD8+ and IL-10 significantly decreased,while CD8+ and IFN-γ increased noticeably(P0.01).After treatment of Xiyanping,CD4+,CD4+/CD8+ were significantly raised,while CD8+ was decreased(both P 0.01).However,patients treated with ribavirin didn't show significant improvement of CD4+ or CD4+/CD8+(P0.05).The disappearance time of fever and herpes in patients treated with Xiyanping were significant shorter,and total effective rate(87.18% vs 77.32%)was higher than that of patients treated with ribavirin(all P 0.01).Coclusions:Xiyanping injection can improve immune function for children with herpangina.It shows better therapeutic effect than that of ribavirin and is worth for application in large scale.
【Fund】: 海南医学院科研基金资助学报项目(0020100260)~~
【CateGory Index】: R725.6
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