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《Journal of Hainan Medical University》 2016-11
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Clinical value of serum amylase,serum trypsinogen-2,IL-10 and platelet activating factor detection for diagnosis of post-ERCP pancreatitis

WANG Di;LI Xue-song;CAI Peng-peng;Department of Gastroenterology,The Third Affiliated Hospital of Qiqihar Medical University;  
Objective:To explore the clinical value of serum amylase,serum trypsinogen-2,IL-10 and platelet activating factor detection in the diagnosis of post-ERCP pancreatitis.Methods:A total of 256 patients with ERCP were selected.According to different symptoms,signs,serum amylase and pancreatic CT examination results after ERCP,the subjects were divided into three groups:control group,hyperlipidemia group and PEP group.Serum amylase,serum trypsinogen-2,IL-10,platelet activating factor were detected and compared between these groups.Results:There were significant differences in serum amylase,serum trypsinogen-2,IL-10,platelet activating factor(F_(group)=269.578、139.492、145.637、126.891,all P=0.000)between the three groups.The serum amylase,serum trypsinogen-2,IL-10,platelet activating factor were statistically significant at each time point(F_(time)=602.506、494.375、462.512、239.564,all P=0.000),the serum amylase level in the patients with hyperlipidemia group reached the highest value after 4h,but at 24 hit was lower than the normal level after undergoing surgery.Serum amylase in PEP group increased rapidly after 4h,and 24 hafter undergoing the surgery,IT was still increasing.The serum trypsinogen-2,IL-10,platelet activating factor were all achieved the highest level 4hafter undergoing operation in the hyperlipidemia group and PEP group,and the 24 hafter the operation they were all decreased.In PEP group,serum amylase,serum trypsinogen-2,IL-10,platelet activating factor at 4h after the operation and 24 hafter the operation were significantly higher than those before undergoing the surgery(F_(interactive)=28.492、22.614、16.573、7.819,all P=0.000).In PEP group,the serum amylase was positively correlated with serum trypsinogen-2,IL-10,platelet activating factor(r=0.591、0.662、0.681,all P0.05).Conclusion:Serum amylase,serum trypsinogen-2,IL-10 and platelet activating factor detection have important clinical diagnostic value in patients with post-ERCP pancreatitis.
【Fund】: 黑龙江省卫生厅科研课题(2014-877)~~
【CateGory Index】: R576
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