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《Journal of Clinical Research》 2006-02
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The Relation Between the Change of Blood Lipid Levels and Type 2 Diabetic Nephropathy

LI Qing,GONG Xi-li,LIU Yu-jin(Department of Endocrinology,Xiangdong Hospital,Hunan Normal University,Liling,Hunan,412200,China)  
【Objective】To investigate the relation between the change of blood lipids and type 2 diabetic nephropathy.【Methods】There were 273 diabetes mellitus patients in our department from 2001 to 2004.There were 141 cases of diabetes mellitus without nephropathy,51 cases with early stage diabetic nephropathy,46 cases with diabetic nephropathy and overt proteinuria,35 cases with end-stage diabetic nephropathy.Serum level of their lipids,blood sugar,urine albumin,serum creatinine,and insulin urea nitrogen were monitored and their levels were compared in the four groups.【Results】The level of serum TG,TC,LP(α),LDL-C,ox-LDL,HbA1c,FPG,FINS were significantly increased and HDL-C was decreased in the three groups of diabetic nephropathy,There was significant difference between the group of diabetes mellitus without nephropathy and the three groups with diabetic nephropathy(P0.05).The concentrations of blood LP(α),LDL-C,ox-LDL were significantly higher in the three groups with diabetic nephropathy than in the group of diabetes mellitus without nephropathy,and the levels were obviously increased with the development of the diabetic nephropathy in the three different stages of diabetic nephropathy(P0.05).【Conclusion】Disorder of lipid metabolism is a risk factor of diabetic nephropathy.Disorder of blood LP(α),LDL-C,ox-LDL metabolism may be independent risk factors of diabetic nephropathy.
【CateGory Index】: R692
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【References】
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1 Deng Ju-hui,Gong Yang-bin,Xue ping(The Clinical Laboratory,Medical Examination Center of General Hospital of Chengdu Military Area,Chengdu 610083,China);The Effect of Serum Lipoprotein(a) on the Early Diagnosis of TypeⅡ Diabetic Nephropathy[J];Medical Journal of National Defending Forces in North China;2007-05
【Citations】
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1 WANG Hongman *, DENG Huacong, LIU Wanli. *Department of Endocrinology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, China;The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus[J];Chinese Journal of Internal Medicine;2002-03
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【Co-references】
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1 CHENG Hui,JIA Ru-han,LIU Hong-yan.Renmin Hospital of Wuhan University,Wuhan 430060,China;Effects of Astraglus on renal injury of diabetic rats[J];Journal of Chinese Physician;2006-10
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【Secondary References】
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1 SUN Qin-min,SUN Guo-hua,BAO Li-li(Department of Clinical Laboratory,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China);Determination of serum homocysteine in type 2 diabetes and evaluate its clinical significance[J];Journal of Dalian Medical University;2008-05
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【Secondary Citations】
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