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《Journal of Clinical Research》 2006-11
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Experimental Study of Qi Jia Mixture on Mesangial Proliferative Glomerulonephritis

QIAN Yu-run, GONG Xue-zhong, ZHOU Ling-fang,et al(Department of Nephrology,The Third People's Hospital,School of Medicine,Shanghai Jiao-tong University,Shanghai 201900,China)  
[Objective]To explore the effect and mechanism of Qi Jia Mixture on rabbit model of mesangial proliferative glomerulonephritis (MesPGN) .[Methods]Rabbit model of MesPGN was created according to Wu Heng Shengs article.Twenty four hours urinary protein, renal function and blood-lipid were observed after treatment of Qi Jia Mixture.[Results]Twenty four hours urinary protein in the model was significantly increased as compared with control. Lipid-metabolism was abnormal. Qi Jia Mixture significantly improved rabbit model of MesPGN in urinary protein and abnormal lipid-metabolism. [Conclusion]The mechanisms of Qi Jia Mixture in treating MesPGN may be related to correction of abnormal lipid-metabolism.
【Fund】: 上海交通大学医学院资助项目(项目号:04XF21102)
【CateGory Index】: R285.5
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