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《Journal of Clinical Research》 2007-07
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The Expressions and Significance of P16. Cyclin D_1 Proteins in Cholangiocarcinoma

YUAN Song-ling1,TANG Hui-huan2(1.Department of Surgery,the First Hospital of Changde,Hunan 415000;2.Department of Surgery,Xiangya Hospital,Central South University,Changsha,410008,China)  
【Objective】To investigate the relationship between the expression of P16 and Cyclin D1 proteins,and define the association of these proteins with clinicopathological characteristics,lymphatic metastasis of cholangiocarcinoma.【Methods】The expressions of P16 and Cyclin D1 protein were studied by streptoavidin-biotin complex.Paraffin sections from 45 cholangiocarcinomas and 10 normal(extrahepatic)bile duct specimens were examined.【Results】P16 expressed faintly in 100% of normal bile duct specimens,and no Cyclin D1 protein was detected in normal bile duct.The positive rates of P16 and Cyclin D1 in cholangiocarcinoma were 37.78%、66.67%respectively.The expression of P16 protein was significantly lower in cholangiocarcinoma than in normal bile ducts(P0.05).The expression of Cyclin D1 protein was significantly higher in cholangiocarcinoma than in normal bile duct.P16 expression was associated with clinical stage significantly(P=0.015),the positive rate of Cyclin D1 protein was associated with clinicopathological stage significantly(P=0.002),Between two proteins studied,expression of P16 and Cyclin D1 was inversely correlated(r=-0.374,P0.05).【Conclusion】Loss of P16 protein expression is a common event in the molecular oncogenesis and progression of extrahepatic bile duct carcinoma(EBDC)(P0.05).Cyclin D1 over expression is a common event in the molecular oncogenesis and progression of EBDC(P0.01).P16 protein expression is inversely correlated with Cyclin D1 expression.Loss of P16 protein expression and Cyclin D1 protein over expression act in cooperative ways to promote the molecular oncogenesis and progression of EBDC.
【CateGory Index】: R735.8
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