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《Journal of Clinical Research》 2007-11
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Expression and Relativity of Cyclooxgenase-2 and Nuclear Factor κB in Rat Lung Tissue of Acute Lung Injury

ZHANG Li-na,GONG Hua,AI Yu-hang(Department of intensive care unit,xiangya Hospital,Central South University,Changsha,410008,China)  
【Objective】To observe expression and relativity of cyclooxgenase-2 and NF-κB in rat lung tissue and discuss the mechanism of NF-κB in acute lung injury.【Methods】The SD rats were injected lipopolysaccharide to establish the model of acute lung injury.Blood gas and wet/dry weight ratio(W/D) of lung were measured.The expression of cyclooxgenase-2 and nuclear factorκB were measured by immunohistochemical method.【Results】The PaO2 of rats in acute lung injury group significantly decreased compared with natural group.W/D increased in acute lung injury group(P0.05).Cyclooxgenase-2 and nuclear factorκB expressed a little in plasm in normal rats lung.But cyclooxgenase-2 expressed massively in rats lung tissue of acute lung injury.at the same time,the expression of nuclear factor κB transfered from plasm to nucleus.The correlation between them were high(r=0.924).【Conclusion】The expression of cyclooxgenase-2 and nuclear factorκB significantly increases in acute lung injury.They are highly correlated.
【CateGory Index】: R563.8
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【References】
Chinese Journal Full-text Database 1 Hits
1 GAO Wei1,2,ZHANG Dong2,LIU Jiang-wei2(1 Medical College of Shihezi University,Shihezi,Xinjiang 832000 China;2 Department of hepatobiliary Surgery,Urumuqi General Hospital of Lanzhou Military region Urumuqi 830000,China);Cyclooxygenase -2 and Lung injury[J];Progress in Modern Biomedicine;2009-15
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 CHENG Shi, SONG Maomin, SHI Jingdong. Department of General Surgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, P. R. China;Effects of nuclear factorκB activation on expression of inflammatory mediators of alveolar macrophages associated with acute necrotizing pancreatitis[J];Chinese Journal of Hepatobiliary Surgery;2006-11
2 WANG Jin-sheng, CHEN Zheng-tang, QIAN Gui-sheng, et al. Institute of Respiratory Disease, Xinqiao Hospital, third Military Medical University, Chongqing 400037, China;Changes of cyclooxygenase isoenzyme and effects of meloxicam in acute lung injury induced by lipopolysaccharide[J];Chinese Journal of Critical Care Medicine;2001-03
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