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《Guiding Journal of TCM》 2006-08
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Effects of the Extract of Gingko Leaf Ginaton on Acute Lung Injury Caused by Lipopolysaccharide in Mice

Objective: To observe if the extract of gingko leaves,ginaton,has a protection on the acute lung injury caused by lipopolysaccharide(LPS).Method: the mice models of acute lung injury were created by injecting LPS into abdominal cavity,the pretreatment was done with the ginkgetin glycoconjugate ginaton injection respectively at 12 and 2 hours prior to LPS damage,some targets,such as the ratio between wet and dry weight in lung tissue,the concentration of albumen in bronchoalveolar lavage fluid,the change of lipid peroxidation product MDA and NO in lung tissue,the effects on pathological changes in lung tissue,were observed.Result: The pretreatment of Ginaton injection could effectively decrease the ratio between wet and dry weight in lung tissue,the concentration of albumen in bronchoalveolar lavage fluid to raise up,which was caused by LPS(P0.05,P0.01);and lower the content of MDA and NO,lighten the pathological change of lung.Conclusion: The pretreatment of Ginaton has an obvious protection on the acute lung injury caused by LPS.
【Fund】: 湖南省财政厅、教育厅高校科研基金(05C016)
【CateGory Index】: R285.5
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