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《Guiding Journal of Traditional Chinese Medicine and Pharmacy》 2010-06
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Yigan icariin Epimedium particles and pharmacokinetic study in rats

Peng Wenda Hunan Mawangdui nursing homes,Changsha 410001  
Objective:Using high performance liquid chromatography to study the liver and particles and icariin in epimedium extract in rats Pharmacokinetics difference of compatibility of the active component metabolism.Methods:Rats were administered Yigan particles,epimedium extract,after tail vein blood at different time points,through the creation of high performance liquid chromatography and sample preparation methods,detection of icariin in rat plasma concentration.3P87 pharmacokinetic program using the obtained results were statistically treated concentration to determine the pharmacokinetic model and the relevant pharmacokinetic parameters.Results:Liver and particles and icariin in Epimedium in rats showed twocompartment open model,Yigan particles and epimedium extract Tmax,Cmax,AUC,t1/2(a),CL indicators comparison,the differences were statistically significant.Conclusion:The compound icariin in vivo process of the significant effects of icariin Yigan particles in rats increased the absorption,distribution,and peak time extension,reduction of plasma clearance,bioavailability than Epimedium herbal high,the cause may be related compound in the interaction of other components.
【Key Words】： Pharmacokinetics icariin
【CateGory Index】： R285.5
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