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《Journal of Practical Diagnosis and Therapy》 2006-05
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Study on the relationship between serum high sensitive C-reactive protein level and cardiovascular events and morality in maintenance hemodialysis patients

ZHANG Dong,CHEN Xiangmei,WEI Ribao,et al.Department of Nephrology,General Hospital of PLA,Kidney Center and Key Laboratory of PLA,Beijing 100853,China  
Objective To investigate serum high sensitive C-reactive protein level and its correlation with cardiovascular events and morality in maintenance hemodialysis patients.Methods Ninety-one patients with maintenance hemodialysis were followed up for more than 3 months in our dialysis center before Dec 2001.The serum levels of high sensitive C-reactive protein,albumin,prealbumin,transferin,triglyceride,cholesterol were determined at the beginning of study.These patients were divided into elevated high sensitive C-reactive protein group(high sensitive C-reactive protein≥3 mg/L)and normal high sensitive C-reactive protein group(high sensitive C-reactive protein3 mg/L).The mortality and cardiovascular events were recorded during the period of follow up.Results The elevated high sensitive C-reactive protein group had higher mortality and more cardiovascular events than normal high sensitive C-reactive protein group.Conclusion High sensitive C-reactive protein is a sianificant predictor of death in chronic dialysis patients,independent of serum albumin and other possible confounders maintenance hemodialysis patients with high sensitive C-reactive protein levels should be carefully evaluated and monitored regardless of serum albumin concentrations in the normal range.
【CateGory Index】: R459.5
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