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《Journal of Chinese Practical Diagnosis and Therapy》 2008-07
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Effect of combination therapy of subhypothermia and erythropoietin on vital signs and internal environment of asphyxied neonates

GUO Xiaoyan,ZHU Changlian,CHENG Xiuyong,et al.Department of Pediatrics,Central Hospital of Luohe,Luohe 462000,China  
Objective To explore the safety of combination therapy of systemic subhypothermia and erythropoietin on asphyxiated neonates.Methods Sixty-five asphyxiated newborns enrolled in this study were randomly divided into combination group(n=16),hypothermia group(n=24) and conventional group(n=25).Sign vitals,blood glucose,electrolytes and blood gas were all monitored before treatment as well as after treatment.Results(1)Heart rate decreased in both combination group and hypothermia group during hypothermia treatment,but increased gradually with the recovery of body temperature.Respiration was steady.There were no obvious changes in blood pressure in combination group,though the dilation pressure at 72 hours showed statistical difference compared with that at 0 hour.(2) Blood natrium, kalium and glucose showed no obvious changes,but blood calcium decreased after combination treatment.(3) There was no significant change in PCO2 during the combination treatment.All the asphyxia infants had metabolic acidosis before treatment and were gradually corrected after therapy.Conclusion Combination therapy of systemic subhypothermia and erythropoietin has no adverse effects on vital signs and internal environment of neonatal asphyxia.
【Fund】: 河南省重点科技攻关项目资助(0122032100)
【CateGory Index】: R722.12
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