Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chinese Practical Diagnosis and Therapy》 2010-02
Add to Favorite Get Latest Update

Influence of ulinastatin on the concentration of cell adhesion molecules and the protective effect on lung injury in cardiopulmonary bypass

FAN Lili,YU Xiangyou. Intensive Care Unit,the First Affiliated Hospital to Xinjiang Medical University,Urumqi 830054,China  
Objective To study the effect of ulinastatin on the concentration of cell adhesion molecules and the protective effect on lungs function in cardiopulmonary bypass. Methods Forty-two patients undergoing cardiac valve replacement were randomly divided into control group (group C),group U1 (given 8 000 u/kg ulinastatin) and group U2 (given 12 000 u/kg ulinastatin). The plasma TNF-α and sICAM-1 concentrations were determined before operation,and 1,4,24 hours after terminating cardiopulmonary bypass respectively. At the same time points,artery blood gas analysis was done to calculate alveolar-arterial oxygen difference and respiratory index. Results In three groups,alveolar-arterial oxygen difference,respiratory index,levels of TNF-α and sICAM-1 increased after terminating cardiopulmonary bypass (P0.05). Compared with control group,these indexes were lower in group U1 and U2 (P0.05). Compared with group U1,these indexes were lower in group U2(P0.05). Conclusion TNF-α and sICAM-1 are closely related to the lung injury in cardiopulmonary bypass. Ulinastatin 12 000 u/kg can significantly inhibit the inflammatory cytokine and cell adhesion molecules,reduce the inflammatory response,lessen the lung inflammatory response to cardiopulmonary bypass and improve lung function.
【Fund】: 新疆医科大学第一附属医院科研奖励基金(编号:2007-YFy-10);; 新疆维吾尔族自治区重点学科(外科学)建设经费(2004—2008)
【CateGory Index】: R654.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved