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《Journal of Chinese Practical Diagnosis and Therapy》 2011-12
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Relationship of the expression of the survivin protein with C-erbB-2 gene and drug-resistance-associated genes in breast cancer tissues

SHI Wei-jian1),WANG Yu-zhi2),LI Quan-yong1),PAN Cheng-xin3),MI Xian-jun4) 1) Department of Oncology,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;2) Department of Prevention and Health Care,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;3) Department of Breast Surgery,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;4) Department of Pathology,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China  
Objective To explore the relationship of the expression of survivin protein with C-erbB-2 and drug-resistance-associated genes in breast cancer tissues.Methods The expressions of survivin protein,C-erbB-2 gene and drug-resistance-associated genes were detected with streptavidin-peroxidase immunocytochemical assay in 51 specimens of breast carcinoma.Results The total positive rate of survivin protein was 68.63%.There was significant difference in the expression of survivin protein between lymph node metastasis and estrogen receptor levels(P0.05),and no significant difference between the different sizes of tumor(P0.05).The expression of survivin protein was higher in the positive expressions of C-erbB-2,lung resistance protein,thymidylate synthase and P-glycoprotein than that in the negative expression ones(P0.05).There was no significant difference between the positive and negative expression of glutathione S-transferase(P0.05).Conclusion Survivin protein plays an important role in the occurrence and development of breast cancer.The detection of survivin can guide the prognosis and further therapy of breast cancer.
【Fund】: 广东省中山市科技计划项目(20082A122)
【CateGory Index】: R737.9
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