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《Journal of Chinese Practical Diagnosis and Therapy》 2013-05
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Mechanism of quercetin on the invasion ability of cervical cancer cell

CHENG Jing,ZHANG Wei,LV Qiong-ying,ZHANG Wen-ting,ZHONG Ya-juan(Department of Gynaecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan 430060,China)  
Objective To investigate the mechanism of quercetin on the invasion and metastasis of cervical cancer and the relationship with heparanase(HPA).Methods Four cell model groups were constructed as cervical cancer Hela cell group(control group),quercetin treatment group,HPA gene silencing group and HPA gene silencing plus quercetin treatment group.Transwell small room method was used to observe the change of invasion ability of cervical cancer cell at different time points.Results In 6,12,24 hours,the migration of cervical cancer Hela cell decreased significantly in quercetin treatment group and HPA gene silencing group compared with control group(P0.01),and there was no significant difference between quercetin treatment group and HPA gene silencing group(P0.05).The migration of cervical cancer Hela cell was lower in HPA gene silencing plus quercetin treatment group compared with the other groups(P0.01).Conclusion Quercetin can significantly inhibit invasion ability of cervical cancer cell.Heparanase is correlated with the invasion process of cervical cancer cell,and the inhibition of quercetin in cervical cancer invasion ability may be correlated with HPA.
【Fund】: 国家自然科学基金(31170329)
【CateGory Index】: R737.33
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