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Effect of ulinastatin on protecting vascular endothelial cells in sepsis rats

YU Zhao-xi;SHI Song-jing;SHEN Yang-hui;Intensive Care Unit of Department of Internal Medicine,Provincial Clinical Medical College of Fujian Medical University;  
Objective To explore the effect of ulinastatin on protecting vascular endothelial cells by inhibiting the expression of nuclear factor-κB(NF-κB)in sepsis rats.Methods Forty-five Wistar rats were randomly divided into three groups:sham operation group,model group and ulinastatin group,with 15 rats in each group.The sepsis rat models were established with cecal ligation and puncture.Sham operation group and model group were given normal saline,and ulinastatin group was given 20u/g ulinastatin with peritoneal injection totally for 3 days.The levels of serum von Willebrand factor(vWF),soluble intercellular adhesion molecule-1(SICAM-1)and soluble thrombomodulin(sTM)as well as NF-κB in thoracic and abdominal aorta tissue were detected 72 hours after models were established.Results The levels of serum vWF,SICAM-1,sTM and NF-κB p65 in ulinastatin group were significantly higher than those in sham operation group(P0.01),and lower than those in model group(P0.01).Conclusion Ulinastatin may protect vascular endothelial cell by inhibiting the expression of NF-κB in sepsis rats.
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