Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Journal of Chinese Medicine》 2011-01
Add to Favorite Get Latest Update

The Study of the Protect Effect of Scutellarin on the Endothelial Cells Induced by Hydrogen Peroxide

Cui Lin1, Yu Hai-bin1, Li Qiang1, Liu Wei-hong1, Ma Chun-fen2 The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450000 The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450002  
Objective: To explore the protective effects of scutellarin on vascular endothelial cell injury induced by oxidative hydrogen.Methods: Preincubate with different concentrate of scutellarin and VE,1 mmol·L-1 Peroxide hydrogen(H2O2) was used to induce injury of human umbilical vein endothelial cells(HUVEC).The cell survival rate was evaluated with MTT assay to explore the protective effect of scutellarin on injury of vascular endothelial cells.The activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and catalase(CAT) was detected in H2O2-induced HUVEC injury.Results: HUVEC was incubated with 1 mmol·L-1 H2O2 for 4 h,the cell viability decreased significantly(P﹤0.05 vs normal control group);scutellarin can promote the cell viability of HUVEC induced by H2O2(P﹤0.05 vs H2O2-injury group);scutellarin could concentration-dependently protect the activity of SOD and GSH-PX(P﹤0.05 vs H2O2 injury group).Conclusion: Scutellarin showed protective effects on vascular endothelial cells induced by oxidative stress and the probable mechanisms may be closely associated with its promoting the activity of antioxidases.
【Fund】: 云南省自然科学基金项目(编号:2004C0019Q)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Yan Yun-zhen(Chongqing Xiushan Chineses Medical Hospital,Xiushan 409900);Effect of breviscapine on cerebral ischemia-reperfusion injury[J];Sichuan Journal of Physiological Sciences;2008-03
2 WANG Li-xiang~1,ZENG Ji-ping~2,HUANG Zi-fang~3,LIU Zhao-ping~1,WEI Xin-bing~1,WANG Zi-ying~1,AN Jie~1,ZHANG Xiu-mei~1(1.Institute of Pharmacology,2.Institute of Biochemistry and Molecular Biology,3.Clinic Medicine 2001grade,School of Medicine,Shandong University,Jinan 250012,China);Antioxidant effect of scutellarin on PC12 cell injury induced by hydrogen peroxide in culture[J];Chinese Journal of Biochemical Pharmaceutics;2005-06
3 FANG Yun-zhong, YANG Sheng 1, WU Guo-yao 2 (Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing 100850 1Division of Animal Nutrition, Department of Animal Science, China Agricultural University, Beijing 100094 2Departmet of Animal Science and Faculty of Nutrition, Texas A & M University,College Station, Texas USA 77843;FREE RADICALS, ANTIOXIDANTS, AND NUTRIENTS IN RELATION TO HEALTH[J];Acta Nutrimenta Sinica;2003-04
Chinese Journal Full-text Database 10 Hits
1 WU Hai-liang,XU Juan-juan,SHAN Shu-fang,GENG De-gui,FAN Mei-zhen(Anhui Provincial Key Laboratory for Microbial Control,Anhui Agricultural University,Hefei 230036);DPPH free radical scavenging activities of extracts from liquid culture of Acremonium terricola with different solvents[J];Journal of Anhui Agricultural University;2009-03
2 MA Dong-xiao (Teaching and Research Section of Human Bodys Science,Jilin Physical Culture Institute,Changchun,130022,China);Sport oxidant injury and maintenance function with antioxidant[J];Journal of Changchun University;2004-04
3 YAN Feng-wei (Collegeof Life Science,Yangtze University,Jingzhou,Hubei 434025,China;College of Food Science and Technology,Huazhong Agricultural University,Wuhan,Hubei 430070,China) XUE Zhao-hui JIANG Hong WU Mou-cheng (College of Food Science and Technology,Huazhong Agricultural University,Wuhan,Hubei 430070,China);The Anti-oxidative Mechanism and Effect in vitro of Polyphenol-2 from Rapeseed(RSPP-2)[J];Journal of Yangtze University(Natural Science Edition)Agricultural Science Volume;2005-02
4 YU Xiao-ming1,WANG Yong-hui2,LI Pei-bing2,XU Zhi-qin2,NAN Wen-kao2,JIN Hong2(1.Department of Nutrition,General Hospital of Chinese PLA,Beijing 100853,China;2.Research Institute of Hygiene Environmental Medical,Academy of Military Medical Science,Tianjin 300050,China);Effect of supplementation of protein diet on antioxidation in intestinal tract in semi-starvation rats[J];Parenteral & Enteral Nutrition;2007-03
5 ZENG Ting,WU Fei(Food College,Northeast Agricultural University,Harbin 150030,China);Enzyme selection for preparing soybean anti-oxidant peptide[J];Journal of Northeast Agricultural University;2009-04
6 HUANG Hong-Mei,WEI Hua,JIANG Wei,ZHANG Xuan,CHEN Ke,TAN Xu,QU Ping,LIU You-Xue,YANG Li,LI Ting-Yu Nutrition Research Center,Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China;Correlation analysis between serum retinol level and antioxidant abilities under different vitamin A status[J];Journal of the Fourth Military Medical University;2008-10
7 FENG Tao et al (Department of Horticulture,Tianjin Agricultural University,Tianjin 300384);Study on the Free Radical Scavenge Capacity of Elaeagnus angustifolia Extracts[J];Journal of Anhui Agricultural Sciences;2010-08
8 JIANG Zongyong LIU Xiaoyan JIANG Shouqun ZHOU Guilian LIN Yingcai CHEN Fang(The Key Laboratory of Animal Nutrition and Feed (South China) of Ministry of Agriculture,Guangdong Public Laboratory of Animal Breeding and Nutrition,Institute of Animal Sciences,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China);Zinc Requirement of Yellow Broilers Aged from One to Twenty-one Days[J];Chinese Journal of Animal Nutrition;2010-02
9 ZHANG Qingli1,2 TAN Zhiliang2 HE Zhixiong2 ZHANG Enping1 SUN Zhihong2,3(1.Northwest A & F University,College of Animal Science and Technology,Yangling 712100,China;2.Key Laboratory of Processes of Agro-eco-system,Chinese Academy of Sciences,Changsha 410125,China;3.Southwest University,Colege of Animal Science and Technology,Chongqing 400715,China);Effects of Nutrient Restriction on the Antioxidant Capacity of Plasma and Gut Epithelial Tissues in Weanling Lambs[J];Chinese Journal of Animal Nutrition;2010-05
10 YAN Feng-wei(College of Life Science, Yangtze University, Jingzhou, Hubei, 434025, China; College of Food Techology,Huazhong Agricultural University, Wuhan, Hubei 430070,China)ZHU Jian-fei, WU Mou-cheng(College of Food Techology, Huazhong Agricultural University, Wuhun, Hubei 430070, China);Method and Itsr Progress of Evaluating the Effect of Functional Food on Scavenging Free Radicals[J];Journal of Yangtze University(Natural Science Edition) Agri Sci V;2006-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 ZHOU Le-quan,KANG Ya-li,YAN Fu-man,Ding Sheng-yuan,Li Xiao-ying(Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Effects of breviscapine on the intracellular calcium concentration of the hippocampal neurons in rats with pantobrain ischemia-reperfusion[J];Journal of Guangdong Medical College;2007-01
3 Peng Haidong 1,Tu Jinwen 2,Tian Jun 3 1. Department of TCM,Changzheng Hospital,Second Military Medical University,Shanghai 200003 2. Department of Physician,The Subsidiary Hospital of Hubei College of TCM,Wuhan 430061 3. Department of Physician,Th;Effects of Breviscapine on Contents of Water and Calcium of Brain after Cerebral Ischemia-reperfusion in Rats[J];Jounal of Hubei College of Trditional Chinese Medicine;2002-03
4 SHUAI Jie, DONG WeiWei(Dept of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037);Experimental research of PKC inhibitor, erigeron breviscapus on the ischemic/reperfusional brain injury[J];CHINESE PHARMACOLOGICAL BULLETIN;1998-01
5 ZHANG Yan,CHEN Qun,GU Weidong,et al.Department of Anesthesiology,Wuxi Fourth People's Hospital,Wuxi 214062,CHINA;Effects of erigeron on ATP content and release of excitatory amino-acids of the hippocampus after cerebral ischemia/reperfusion injury in gerbils[J];Jiangsu Medical Journal;2005-11
6 HE Wei2, LIU Yi Ming1, CHEN Hui1, ZENG Fan Dian1*(1. Institute of Clinical Pharmacology, Department of Pharmacology, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan 430030, China; 2. Department of Pharmacology, Gannan MedicalCollege, Ganzhou 341000, China);Effect of breviscapine on brain edema and neutrophil infiltration induced by focal cerebral ischemia and reperfusion in rats[J];Chinese Journal of Pharmacology and Toxicology;2004-03
7 WANG Yu1,WANG Lin2,CHEN Yan-zhong3,et al.(1 Xinxiang Central Hospital,Xinxiang,Henan 453000,China;2 Department of Pharmaceutics,Guangdong Vocational & Technical College of Chemical Engineering Pharmacy,Guangzhou,Guangdong 510520,China;3 Institute of Pharmaceutical Science,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510240,China);Effects of breviscapine liposomes on cerebral ischemia and reperfusion in rats[J];Drug Evaluation;2006-02
8 XU Xiao-hong~(1*),CHEN Yu~2,ZHENG Xiao-xiang~2(1.College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua 321004;2.Department of Biomedical Engineering,Zhejiang University,Hangzhou 310013,China);Protective effects of breviscapine against cultured rat hippocampal neuronal toxicity induced by glutamate[J];Acta Pharmaceutica Sinica;2007-06
9 Fang Yunzhong, Lai Yefu, Hu Bin, Zhang Zhongxing (Academy of Military Medical Sciences, Beijing);PROTECTIVE EFFECT OF LIVER, CABBAGE AND YEASTON RADIATION DAMAGE[J];Acta Nutrimenta Sinica;1987-02
10 XUE Zheng, WANG Xue-song, RUAN Xu-zhong (Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China);Effect of erigeron on intercellular adhesion molecule-1 and its mRNA expression during cerebral ischemia and reperfusion in rats[J];Chinese Journal of Pathophysiology;2004-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved