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《China Journal of Chinese Medicine》 2011-01
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The Study of the Protect Effect of Scutellarin on the Endothelial Cells Induced by Hydrogen Peroxide

Cui Lin1, Yu Hai-bin1, Li Qiang1, Liu Wei-hong1, Ma Chun-fen2 The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450000 The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450002  
Objective: To explore the protective effects of scutellarin on vascular endothelial cell injury induced by oxidative hydrogen.Methods: Preincubate with different concentrate of scutellarin and VE,1 mmol·L-1 Peroxide hydrogen(H2O2) was used to induce injury of human umbilical vein endothelial cells(HUVEC).The cell survival rate was evaluated with MTT assay to explore the protective effect of scutellarin on injury of vascular endothelial cells.The activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and catalase(CAT) was detected in H2O2-induced HUVEC injury.Results: HUVEC was incubated with 1 mmol·L-1 H2O2 for 4 h,the cell viability decreased significantly(P﹤0.05 vs normal control group);scutellarin can promote the cell viability of HUVEC induced by H2O2(P﹤0.05 vs H2O2-injury group);scutellarin could concentration-dependently protect the activity of SOD and GSH-PX(P﹤0.05 vs H2O2 injury group).Conclusion: Scutellarin showed protective effects on vascular endothelial cells induced by oxidative stress and the probable mechanisms may be closely associated with its promoting the activity of antioxidases.
【Fund】: 云南省自然科学基金项目(编号:2004C0019Q)
【CateGory Index】: R285.5
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