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《JOURNAL OF HUNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE》 2000-01
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THE EFFECTS OF CYCLOPHOSPLAMIDE ON SPERMATOGENESIS IN MICE

Chen An;Sun Hongxi; Xiong Aijun (Department of Basic Medicine, Hunan College of TCM,Changsha 410007)  
Cyclophosplamide(CY)were injected intrapertontally to male mice. On the 21. 28. 34.36 d after administration,the changes of sperm and testis tissue in mice were observed. The results showed that on the 34.36 d the total sperm count decreased(P0. 01),and the deformity rate of sperm increased (P0. 01 ),on the 21. 28. 34. 36 d the number of spermatogenic cells decreased(P0. 05 or P0. 01),the ultrastructural changes (36 d ) were mainly break of nuclear membrane, injury of nuclear in the spermatogenic cells and abnormal acrosomic vesicle in spermatid,but the tight junction were normal. The results indicated that directly injuring the spermatogonia and spermatocyte at DNA-synthetic phase was the way by which CY disturbed the mice's spermatogenesis.
【Fund】: 湖南省科委资助!92-24004
【CateGory Index】: R979.1
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【References】
Chinese Journal Full-text Database 3 Hits
1 HE Da-wei,LI Xu-liang,YUE Li-qing,WEI Guang-hui,LIN Tao,LIU Jun-hongDepartment of Pediatric Urology,Children's Hospital,Chongqing Medical University,Chongqing,400014,China;Effect of Cyclophosphamide on Spermatogonial Stem Cells[J];National Journal of Andrology;2006-05
2 WANG Rui,XU Lei,ZHANG Wei-xing,WU Yu-feng,SHI Jian-hua,ZHANG Yue-xiDepartment of Urology,The First Hospital Affiliated to Zhengzhou University Open Laboratory for Clinical Medicine,Key Discipline of Henan Higher Education,Zhengzhou,Henan 450052,China;Shengjing Granule:An Effective Chinese Medicine for Spermatogenic Disturbance in Mice[J];National Journal of Andrology;2008-11
3 YUE Li-qin, LI Xu-liang, WEI Guang-hui, LIN Tao, HE Da-wei, LIU Jun-hong, CHEN Zhi-yuan. Department of Pediatric Urology, Chongqing Children's Hospital, Chongqing 400014, China;Toxic effect of cyclophosphamide on the rat spermatogenesis in different developmental phases of testes[J];Chinese Journal of Pediatric Surgery;2006-01
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Department of Toxicology Yun Shumei,et al;THE EFFECT OF VINY CHLORIDE ON THE MORPHOLOGY OF MOUSE SPERM[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1995-04
2 Zhang Xue-Shu, Zhu Jin-Liang, Zhou Yuan-Fen,Jiang Xue-Zhi, Wang Yi-Lan(Department of Occupational Health, School of Fublic Health,Shanghai Medical University, Shanghai);STUDY ON THE EFFECTS OF LEAD ACETATE ON SPERMATOGENESIS IN MALE MCIE[J];;1993-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHEN Xiao ming, LI Meng, PIAO Tai hu tutor:DU Yuan hao (1999 Grade Doctorate Student, Tianjin College of Traditional Chinese Medicine, Tianjin 300193,China);EFFECT OF ACUPUNCTURE WITH PRINCIPLE OF REGULATING MENTALITY AND SUPPLEMENTING KIDNEY ON EFFECTOR ORGANS OF ESTROGEN IN CLIMACTERIC RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-01
2 Wu Xiao Ying1,2,3, Li Cui1,2, Xiao Zhi Qiang1, Li Jian Ling1, Feng Xue Ping1, Yi Hong1, Li Mao Yu2, Chen Zhu Chu1,2 1. Medical Research Center, Xiangya Hospital,Central South University,Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Changsha,Hunan, 410008,P.R.China 2. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha,Hunan,410078, P.R.China 3. Department of Medical Ultrastructure,College of Basic Medicine,Central South University, Changsha,Hunan,410078, P.R.China;2-DE Profiling and Differential Analysis of Human Bronchial Epithelial Tissues in Different Stages of Carcinogenesis[J];Chinese Journal of Cancer;2004-05
3 LIU Tong1,WANG Dong-mei2(1.Department of Histology and Embryology,Bengbu Medical College,Bengbu 233003;2.Suzhou Municipal Health School of Anhui Province,Suzhou 234000,China);Expression of proliferating cell nuclear antigen during liver regeneration process after partial-hepatectomy in rats[J];Journal of Bengbu Medical College;2005-04
4 CHEN Yu-Qin,YU Shi-Yuan,ZHANG Hu-Lin,ZHANG Jing,SHANG Jian-Ke,XIE Ming-Ren College of Life Science,Northwest Normal University,Lanzhou 730070,China;Histological structure and expression of EGFR,TGF-β,AQP-2 in Chrysolophus pictus kidney[J];Acta Zoologica Sinica;2008-02
5 CHEN Yu-Qin YU Shi-Yuan ZHANG Hu-Lin ZHAO Zhong-Hui ZHAO Xiu-Mei(College of Life Science,Northwest Normal University,Lanzhou 730070,China);Histological Observation on the Development of Chick Embryonic Kidney[J];Chinese Journal of Zoology;2008-03
6 Liu Hongyu,et al(Department of Anatomy, Binzhou Medical College);THE FUNDAMENTAL STUDY ON ACTIVITY OF γ-GLUTAMYLTRANSFERASE IN MOUSE IN PROCESS OF RENOVATION FOLLOWING TRAUMATIC BRAIN INJURY[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1995-05
7 ZHAO Shu min,SUN Xiao yong,MA Wei jun,et al (Laboratory of Electron Microscopy,Chengde Medical College,Hebei Chengde 067000,China);OBSERVATION ON ULTRASTRUCTURES OF THE OLFACTORY BULB NEURON FROM AGED RATS[J];Journal of Chengde Medical College;2001-03
8 MA Quan,LI Jian,HAN li,et al (Chengde Medical College,Hebei Chengde 067000, China);OBSERVATION OF OVARY MICROVASCULATURE WITH TANNIC ACID-FERRIC CHLORIDE STAINING UNDER THE LIGHT MICROSCOPE[J];Journal of Chengde Medical College;2004-01
9 REN Ping, LIU Fang, HUANG Xi, et al (Xijing Hospital, Fourth Military Medical University,Xi'an, 710032, China);Experimental Study on Changes of Enteroendocrine Cells of Somatostain, Motilin and Cholecystokinin in Splenic Asthenia Rat Model[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2001-01
10 site in the process of fracture healing in rabbits TAN Chun hua,ZHOU Yue (Department of Orthopaedic Surgery,161st Hospital of PLA,Wuhan,Hubei 030010,China);Experimental study on the effect of micro-drilling on both segments of bone near fracture[J];Journal of Traumatic Surgery;2001-01
China Proceedings of conference Full-text Database 1 Hits
1 SUN Jiamin CHEN Nanqing WU Tonghe.The Second Hospital of Longyan,Fujian 364000,China;Study on Preinducing the Adult Animal Hepatocytes for Boosting the Metabolic Activity of Bilirubin[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Liu Huiwen;Li Cun;Jin Lianhong;Liu Zhiyu;Li Xuejun (Department of Histology and Embryology, Neural Internal Medicine of 2nd Hospital,Computer Centre, Harbin Medical Uniuersity);MORPHOLOGICAL STUCIES ON THE DEVELOPMENT OF GERM CELLS OF RAT TESTIS[J];ACTA ANATOMICA SINICA;1996-02
2 ZHENG Jian,ZENG Zhangchao GUO Yunxia Fujian People's Hospital,Fuzhou,Fujian (350004)$$$$;Treatment of Frequently Recurrent Nephritic Syndrome in Children with Shenkangling Granula:An Observation on 30 cases[J];Chinese Journal of Integrated Traditional and Western Nephrology;2002-04
3 Xin ZENG, Si-Fan XU (Department of Physiology, Jiangxi Medical College, Nanchang, Jiangxi 330006, China);Advances in the Research of Spermatogonial Stem Cell[J];Acto andrologica Sinica;2003-04
4 HE Da-wei,LI Xu-liang,YUE Li-qing,WEI Guang-hui,LIN Tao,LIU Jun-hongDepartment of Pediatric Urology,Children's Hospital,Chongqing Medical University,Chongqing,400014,China;Effect of Cyclophosphamide on Spermatogonial Stem Cells[J];National Journal of Andrology;2006-05
5 WANG Yi-xin,ZHENG Ju-fenDepartment of Urology,Affiliated Renji Hospital,Shanghai Jiaotong University Medical College,Shanghai Andrology Institute,Shanghai 20001,China;Male Infertility Update[J];National Journal of Andrology;2006-09
6 Zheng Jiashen Zhejiang Huzhou Maternal & Child Hygiene Hospital(31300);Study on the correlation between endocrine hormone and sperm density of infertile male[J];;1999-01
7 Chen Xiaolan, Duan Xiaomao, Tang Yinjuan, Mo yanxiu, Liu Kefeng Department of Histology and Embryology, Xiangnan College, Chenzhou 423000, China Duan Xiaomao Department of Pharmacology, Xiangnan College;Experimental study on the effect of Zan Yu Yan Sheng Yin on spermatogenesis disturbance of rats[J];Chinese Journal of Andrology;2006-11
8 Zhou Ying(advisors: Liang Guozhen Luo Songping) Seven-year-graduate Class, Grade 91, Guangzhou University of TCM, Guangzhou 510407;Genitality in SD Rats with Spleen Deficiency and Kidney Deficiency[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-03
9 Wen Zhijian et al Sichuan Institute of Chinese Materia Medica,Chongqing 630065;Experimental Studies on Fushouwei,an Antiaging Compound Chinese Medicine[J];Sichuan Journal of Physiological Sciences;1995-Z1
10 Wu Liqun,Ding Ying(The Second Hospital of Shanxi Colleg e of TCM,Taiyuan Shanxi 030024);Clinical Observation on Children' s Refractory Nephrotic Syndrome Treated with Yiqi Zishen Huoxue Fang:75Cases[J];Journal of Shanxi College of Traditional Chinese Medicine;2002-03
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 XU Lei,WANG Rui,ZHANG Weixing,WU Yufeng Department of Urology,the First Affiliated Hospital,Zhengzhou University;Henan Provincial Open Key Laboratory of Clinical Medicine,Zhengzhou 450052;Effects of soluble granule of Shengjing on spermatogenesis disturbance induced by cyclophosphamide in mice[J];Journal of Zhengzhou University(Medical Sciences);2008-02
2 LI Xu-liang;Research Development of Antitumor Drug’s Damage to Seminiferous Function and Correspond Proteets[J];Continuing Medical Education;2006-18
3 WANG Rui,XU Lei,ZHANG Wei-xing,WU Yu-feng,SHI Jian-hua,ZHANG Yue-xiDepartment of Urology,The First Hospital Affiliated to Zhengzhou University Open Laboratory for Clinical Medicine,Key Discipline of Henan Higher Education,Zhengzhou,Henan 450052,China;Shengjing Granule:An Effective Chinese Medicine for Spermatogenic Disturbance in Mice[J];National Journal of Andrology;2008-11
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhuang Bijia;The spermotoxicity of lead acetate in mice and its effect on reproductive function.[J];;1991-01
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