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《Journal of Traditional Chinese Medicine University of Hunan》 2009-02
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Effect of Danlong Xingnao tablet on expression of AI,Fas/FasL and TNF-α after cerebral ischemia-reperfusion in rats

HE Qian,LI Hua,ZHOU Xiao-qing,LIU Wang-hua,LIU Jian-xin,ZHANG Guo-min(TCM University of Hunan,Changsha,Hunan 410007,China)  
Objective To investigate the effect of Danlong Xingnao tablet(DLXNT) on ex-pression of AI,Fas/FasL and TNF-α after cerebral ischemic-reperfusion in hippocampus in rats.Methods The model of cerebral ischemia-reperfusion was induced by middle cerebral artery oc-clusion(MCAO) and recanalization.The rats were randomly divided into four groups including sham-operation,control,DLXNT and nimodipine groups.The expression of AI,Fas/FasL,TNF-α in hippocampus were detected with TUNEL and immunohistochemistry.Results DLXNT could reduce obviously the injury of nervous cell;expression of Fas/FasL and TNF-α positive cells existed in sham-operation group,Fas/FasL and TNF-α were increased immediately after cerebral ischemic-reperfusion;compared with model group,the expressions of Fas/FasL and TNF-α were remarkably inhibited in DLXNT group(P0.01,P0.05).Conclusion The effect of DLXNT maybe inhibiting the expression of Fas/FasL and TNF-α induced by cerebral ischemia-reperfusion in-jury.
【Fund】: 湖南省自然科学基金资助项目(07JJ6056);; 湖南省教育厅科研资助项目(07C475)
【CateGory Index】: R285
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