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《Journal of Traditional Chinese Medicine University of Hunan》 2009-04
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Effects of different acupuncturing in Neiguan on reperfusion injury of MI and β-EP in rats

ZHOU Guo-xiang,YI Shou-xiang,LIN Ya-ping,WANG Xiao-shun(TCM University of Hunan,Changsha,Hunan 410007,China)  
Objective To investigate the mechanism of acupuncturing point Neiguan to protect the myocardial ischemia and reperfusion injury and the effect of β-EP.Methods After five days of acupuncture,all rats were bound in anesthesia and their ECG were recorded in whole process.The rats in blank group were bound only,in sham operation group opened their thoracic cavity with no ligation and in model,mild manipulation and strong manipulation groups opened their thoracic cavity to ligature left descending coronary artery which caused myocardial ischemia in 20 minutes and then reperfusion in 40 minutes.Then,carotid blood was taken to be measured the volumes of IMA and β-EP.Results The ST Ⅱ of ECG in model group was higher than that in blank group and sham operation group obviously(P0.01),and lower than that in mild manipulation and strong manipulation groups(P0.01).The IMA and β-EP content in model group were increased significantly compared with the blank group and sham operation group(P 0.01).The ST Ⅱ of ECG,IMA and β-EP in strong manipulation group were lower than that in mild manipulation group(P0.05).Conclusion Acupuncturing point Neiguan can decrease the β-EP content of myocardial ischemia and reperfusion rats to protect the heart muscles.
【Fund】: 国家973计划资助项目(2005CB523306);; 湖南省自然科学基金资助项目(06JJ50049)
【CateGory Index】: R245
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