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《Journal of Traditional Chinese Medicine University of Hunan》 2010-04
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The Study on Correlation between Stress Ulcer and Endotoximia and Lipid Peroxidation after Traumatic Brain Injury in Rats

WANG Tian-yi,MENG Qing-ying,ZHU Yu-qun,YANG Zhao-xu(Department of Gastroenterology,Beijing Tiantan Hospital,Affiliated of Capital Medical University,Beijing 100050,China)  
Objective To explore the correlation between stress ulcer(SU) and endotoximia(ET) and lipid peroxidation(LPO) after traumatic brain injury(TBI).Methods The animal model of TBI was duplicated by modified Feeney’s.32 male Wistar rats were randomly divided into control group and TBI 6,12,24h groups.The ulcer indexes(UI) and contents of ALT,AST,MDA,SOD and lipopolysaccharide(LPS)were detected.Pathological changes were observed through both light microscope and electron microscopic.Results The UI grew significantly,as well as the values of ALT,AST and LPS in each TBI subgroup.Significant positive correlation was found between the values of LPS and ALT,AST,MDA,while significant negative correlation between the value of LPS and SOD.The injuries in both liver and gastric mucosal epithelial cells had been observed through both light and electron microscope.Conclusion ET and LPO may be involved in the pathogenesis of stress ulcer and liver injury after TBI.
【CateGory Index】: R651.15;R573.1
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