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《Henan Traditional Chinese Medicine》 2004-03
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Pathologic Observation of TGF-β Reaction of Gastric Wound Tissues Treated by Danshen Yaomo

Shen Jing 1, Zhu Haiqing 1, Zhao Yi 2, Pan Liquan 2 (1.the Affiliated Brain Diseases Hospital of Nanjing Medical University. Nanjing, Jiangsu, 210029; 2. Nanjing University of TCM. Nanjing, Jiangsu, 210029)  
Purpose: By means of examining the reaction of the transforming the growing factors β of the wound tissues, to explore Danshen Yaomo's effect mechanism in the repair of digestive organ's wound at the level of molecular biochemistry. Method: 36 experimental rabbits were divided into three groups: the group treated by Danshen Yaomo, the group treated by Danshen for the whole body, and the controlled group. After their gastric wall tissues were modelled, the samples of wound tissues were collected respectively 3 days, 7 days, 14 days and 30 days after operation, then the TGF-β reaction was examined by way of immunohistochemical method. Result: In the reaction stage of the local inflammation and the stage of cell multiplication, the TGF-β reaction of the group treated by for the whole body was stronger than the controlled group without treatment, and the group treated by Danshen Yaomo was stronger than the group treated by Danshen for the whole body; while at the stage of tissue formation, there was no remarkable difference among three groups in the TGF-β reaction. Conclusion: Danshen Yaomo can regulate TGF-β reaction to promote the wound repair, and its effect conforms to the basic law of the wound repair.
【Fund】: 国家中医药管理局基金项目 (课题号 :97Z10 4 )
【CateGory Index】: R285
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