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《Henan Traditional Chinese Medicine》 2009-10
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Effects of Breviscapine on SOD,MDA,NO of rats with Cerebral Ischemia-reperfusion Injury

Zhang Xinzhan1,Wang Aijie2,Sui Zaiyun2(1.Central Hospita of Shandong Xinwen Mining Group,Shandong,Laiwu 271103;2.Institute of Traditional Chinese Medicine of Shandong Province,Shandong,Jinan 250014)  
Objective: To observe effects of breviscapine on SOD,MDA,NO of rats with cerebral ischemia-reperfusion injury.Methods: The rats were randomly divided into sham operation group,Ginkgo biloba extract group,high-dose group,medium-dose group and low-dose group,which were given the gavage administration for 10 days to make the middle cerebral artery occlusion model with the line of intraluminal.The SOD activity,MDA and NO levels in serum and brain tissue of the rats were detected.Results: Breviscapine can significantly increase SOD activity in the serum and brain tissues of rats with cerebral ischemia-reperfusion injury while the levels of MDA,NO decreased significantly.Conclusion: Breviscapine can significantly reduce the cerebral ischemia-reperfusion injury through affecting the SOD,MDA and NO.
【CateGory Index】: R285.5
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