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《Global Traditional Chinese Medicine》 2015-01
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Progress on the study of effective constituent of Chinese medicinals inducing cervical cancer Hela cell apoptosis

SHI hai-min;DING Ku-ke;ZHANG xin;The first clinical college,Liaoning University of Traditional Chinese Medicine;  
With the increasing of cervical cancer incidence,the effects of Chinese medicinals in treating cervical cancer radiotherapy and chemotherapy side reaction and postoperative complications were gradually attached importance to. Influencing Bax / Bcl-2 family,Caspase family,Fas / Fasl system and the expression of some related genes could induce cervical cancer Hela cells apoptosis. This article focuses on several kinds of Chinese medicinals,summarizes the faction of the mechanism of effective constituent of these Chinese medicinals in cervical cancer Hela cells apoptosis. For example,the effective constituent of curcuma zedoaria promotes Hela cell apoptosis by down-regulated expression of Bcl-2. The procedure of promoting Hela cell apoptosis of Trichosanthin has relationship with Caspase famlily. The purposes of researching Chinese medicine effective constituent influnes cervical cancer Hela cell apoptosis are providing the scientific basis for treating cervical cancer with Chinese medicine and ideas about filtering new medicines for the cancer.
【Fund】: 国家自然科学基金(30770573/31170806);; 北京市自然科学基金(7092013);; 沈阳市科技攻关计划(F12193948)
【CateGory Index】: R285
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