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《Chemical Industry and Engineering》 2007-06
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Preparation and Content Analysis of Metformin Microemulsion

XU Zhi-bin~1,LIU Ming-yan~1,JIANG Rong-gao~2,WANG Chun-long~2,LIU Zheng-jun~1(1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China)  
Based on the obtained pseudo-ternary phase diagrams,the effects of surfactants,cosurfactants and oils on the microemulsion were studied and the formulations were optimized.From the formulation the stable metformin loaded water-in-oil microemulsion could be prepared using teaoil/Tween 80-Span85/PEG400/water system.The mean diameter of the microemulsions determined by the Photon Correlation Spectroscopy was 46.3 nm with Gauss distribution.The content of metformin loaded in microemulsions was analyzed by UV method.The average recovery by UV method was 99.56% with standard deviation of 1.23%.The metformin microemulsion prepared was pharmaceutically acceptable and the method to determine the concentration of metformin was acute and reliable.
【CateGory Index】: R943
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