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《Progress In Chemistry》 2005-01
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Progress in Metal Complex Conjugated to an Oligodeoxyribonucleotide as Selective Cleavage Reagent

Yuan Caixia Yang Pin **(The Key Laboratory of Chemical Biology and Molecular Engineering, Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China)  
The artificial enzymes, which are prepared by cleavage reagents of nucleic acid conjugated to a synthetic oligodeoxyribonucleotide, can selectively cleave DNA or RNA. It provides a new method of the molecular design of artificial nuclease. In this review the conjugation mode of metal complex with an oligodeoxyribonucleotide and the interaction mechanism of the artificial enzymes with the targets are described, and the research direction in future is pointed out.
【Fund】: 国家自然科学基金资助项目 (No.2 0 1710 31)
【CateGory Index】: O629
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