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《Progress in Chemistry》 2007-11
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Click Chemistry and Its Applications

Li Juan~1 Duan Ming~(2,3**) Zhang Liehui~3 Jiang Xiaohui~1(1.Department of Chemistry,China West Normal University,Nanchong 637002,China;2.Department of Materials Science and Engineering,Southwest Petroleum University,Chengdu 610500,China;3.State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation,Southwest Petroleum University,Chengdu 610500,China)  
Click chemistry is an approach through which large numbers of new compounds can be quickly synthesized by utilizing the most practical and reliable chemical transformations.These reactions can give products in highly yields without special purification and are conducted under mild conditions.In this paper,some basic conceptions of click chemistry are introduced.As a new systhesis method,the application of click chemistry in drug discovery which includes lead discovery libraries,carbohydrates,natural product derivatives,bioconjugation and macromolecule's polymer synthesis are reviewed in detail.At last,future trends of click chemistry is prospected.
【Fund】: 教育部博士点基金项目(No.20040615004);; 高等学校优秀青年教师教学科研奖励计划(TRAPOYT)资助
【CateGory Index】: TQ460.1
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Guolin 1, WU Qiuhua 2, PAN Tong 3, MA Jianbiao 1 ( 1State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071) ( 2School of Chemical Science and Engineering, Liaoning University, Shenyang 110036) ( 3Department of Chemistry, Changsha University of Science and Technology, Changsha 410077);SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC AB DIBLOCK COPOLYMERS OF POLY(γ-BENZYL-L-GLUTAMATE) AND POLY(ETHYLENE GLYCOL)MONOMETHYL ETHER[J];Acta Polymerica Sinica;2004-02
2 LI Zhong-hui, ZHANG Yong-ming, LIU Yan-gang, XUE Min-zhao (College of Chemistry and Technology, Shanghai Jiaotong University, Shanghai 200240, China);ADVANCES OF ATOM TRANSFER RADICAL POLYMERIATION AND IT′S IMMOBILIZED CATALYST[J];Polymeric Materials Science & Engineering;2005-01
3 TANG Xin-de~(a,b),FAN Xing-he~a,CHEN Xiao-fang~a,ZHOU Qi-feng~a(a College of Chemistry and Molecular Engineering,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University,Beijing 100871,China;b Institute of New Materials,Shandong Jiaotong University,Jinan 250023,China);Progress of Atom Transfer Radical Polymerization(ATRP) Applied to the Synthesis of Multiblock Copolymers[J];Chinese Polymer Bulletin;2006-06
4 NIU Yu-zhong,CHEN Hou,CHEN Jian,QU Rong-jun~*(School of Chemistry and Materials Science,Yantai Normal University,Yantai,264025,China);Atom Transfer Radical Polymerization and Polymer Synthesis[J];Chinese Polymer Bulletin;2006-08
5 WU Qiu-hua~1, ZHANG Guo-lin~2 (1.College of Chemical Science and Engineering, Liaoning University,Shenyang 110036,China; 2.College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China);SYNTHESIS AND CHARACTERIZATION OF POLY(BENZYL-L-GLUTAMATE) CONTAINING FUNCTIONAL HYDROXY GROUPS IN MAIN CHAIN[J];Polymeric Materials Science & Engineering;2004-02
6 YUAN Jian-jun 1, CHENG Shi-yuan 1, FENG Lin-xian 2 (1. College of Chemistry and Materials Science, Hubei University, Wuhan 430062, China; 2. Institute of Polymer Science, Zhejiang University, Hangzhou 310027, China);The Self-assembly of Block Copolymer and Its Applications in Fabricating Nanomaterials(Ⅰ)[J];Polymer Bulletin;2002-01
7 LI Juan1,DUAN Ming2,FANG Shen-Wen2, ZHANG Lie-Hui2(1.College of Chemistry and Chemical Engineering,China West Normal University,Nanchong 637002,China;2. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation,Southwest Petroleum University,Chengdu 610500,China);Synthesis of Cyclo-PMMA via Click Chemistry Combined with ATRP[J];Chemical Journal of Chinese Universities;2007-06
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9 ZHENG Xuan,ZHANG Li-wu(College of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400044,China);ADVANCE IN CONTROLLED LIVING RADICAL POLYMERIZATION[J];Polymer Materials Science & Engineering;2006-02
10 ZHANG Su-ning, CHEN Tao, LIN Jia-ping *, LIN Shao-liang, LIU Chang-sheng, TANG Dong-mei, TIAN Xiao-hui (School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China);The Structures and Properties of Polypeptides and Their Applications in Biomaterial Field[J];Polymer Bulletin;2004-03
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