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《West China Journal of Stomatology》 2008-04
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The effect of basic fibroblast growth factor on the gene expression of decorin by periodontal ligament fibroblasts in culture

WANG Si-cong1, LIN Chong-tao1, NIE Dai-bang2, OUYANG Hong-sheng2. (1. Dept. of Periodontology, Stomatology Hospital of Jilin University, Changchun 130041, China; 2. Dept. of Animal Biotechnology, School of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China)  
Objective To study the effect of basic fibroblast growth factor(bFGF) on the gene expression of decorin by periodontal ligament fibroblasts(PLFs) in culture,and discuss the effect of bFGF in periodontal regeneration. Methods Human PLFs were cultured and stimulated by exogenous bFGF. Gene expression of decorin was assessed by semi-quantitive RT-PCR. Results The mRNA expression of decorin was suppressed by bFGF and the effect was dose-dependent. When the dose of bFGF increased, the inhibitive effect decreased. Conclusion Decorin has many biological effects. The inhibitive effect may be one of important factors which participate in the healing process of periodontitis, and provide partly theoretical basis of bFGF in periodontal regeneration.
【Fund】: 吉林省科技发展计划基金资助项目(200705342)
【CateGory Index】: R78
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