Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《West China Journal of Stomatology》 2009-03
Add to Favorite Get Latest Update

Preparation and properties of chitosan film as a drug sustained-release system

JI Juan-juan,DING Zhong-juan,YANG Xue-lian.(Dept. of Prosthodontics,The Affiliated Stomatological Hospital of Kunming Medical College,Kunming 650031,China)  
Objective To develop a best chitosan film for using as a drug sustained-release system through the evaluation of the sustained-release property,degradation property,and cytotoxicity to osteoblast. Methods Orthogonal experiments were designed to determine the best combination of chitosan film preparations. Drug release rate was determined with Coomassie brilliant blue G250. In a separate study,chitosan films were placed into the test tubes with buffer solution and 107 U/L lysozyme. The degradation rate was calculated. Osteoblasts derived from fetal rat calvarial were cultured on chitosan films. Cell proliferation was tested by methyl thiazolyl tetrazolium(MTT) assay. The relative growth rate was calculated and the cytotoxicity was graded. Results The best processing condition was 1% acetic acid,chitosan concentration of 2 mg/mL,6% sodium tripolyphosphate(STPP) concentration,and crosslinking time of one hour. The resulting chitosan film released 33.13% of bovine serum albumin(BSA) within 8 d,36.73% of BSA within four weeks and the cytotoxicity grade was 0 or 1. Conclusion This chitosan film possesses good sustained release property,and a good degradation rate.
【Fund】: 云南省自然科学基金资助项目(2006C0001R)
【CateGory Index】: R94
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 KANG Kai ,ZHANG Qi-qing . Institute of Biomedical Engineering ,China Academy of Medical Science and Peking Union Medical College,Tianjin 300192,China;Progress in carrier for growth factor controlled release in tissue engineering[J];;2005-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIN Ru-cheng et al(Lanzhou University of Technology,Lanzhou,Gansu 730050);Study on Extraction of Astragalus membranaceus Polysaccharides by Optimized Ultrasonic Method with Uniform Design[J];Journal of Anhui Agricultural Sciences;2009-12
2 ZHOU Yuefeng1),WANG Jin'an1,2),HU Jianjun1)1)Civil and Environment Engineering School,University of Science and Technology Beijing,Beijing 100083,China2)Mining and Safety Engineering School,China University of Mining Technology,Xuzhou 221000,China;Design and optimization of bolt and wire mesh support for a tunnel based on the grey-fuzzy theory[J];Journal of University of Science and Technology Beijing;2007-12
3 MENG Chun-ling,ZHANG Li,ZHANG Yang(College of Mechanical Engineering and Automation,Beijing Technology and Business University,Beijing 100037,China);EFFECT OF PHENOLIC RESIN AND REINFORCING FIBER ON ATTRIBUTES OF POLYMER BASED FRICTIONAL MATERIALS[J];Fiber Reinforced Plastics/Composites;2007-06
4 CHEN Yu-guang1,2,LIN Tao1,LIAO Shi-li1(1.Chongqing Institute of Technology,Chongqing 400050,China;2.The Key Lab of Automobile Parts& Test Technique in Chongqing,Chongqing 400050,China);The Optimization of OBDⅡFault Dictionary based on Fuzzy Orthogonal Test[J];Vehicle Engine;2007-06
5 WANG Xian-feng,PENG Mei-chun,WANG Hai-long (Guangdong university of technology,Guangzhou 510090,China);Study on the Optimal Proportion of Diesel/Bio-diesel/Ethanol[J];Vehicle Engine;2008-04
6 Xu Zhe(Shanghai Diesel Engine Co.,Ltd.,Shanghai 200438,China);Application of Uniform Design in Performance Optimization for a Common Rail Diesel Engine[J];Design and Manufacture of Diesel Engine;2009-02
7 TENG Hai-ying1,SONG Mao-hai1,CHENG Liang1,KONG Yu-xiu2,JIANG Jian11.Department of Physics and Mathematics,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China2.Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433;Optimized design for in vitro experiment of electret transdermal patches[J];Academic Journal of Second Military Medical University;2009-05
8 ZHANG Yi1,LI Yanyan2,XU Jinxiang1(1 School of Aerospace Science and Engineering,Beijing Institute of Technology,Beijing 100081,China;2 No.61081 Unit,Beijing 100094,China);Research on Trajectory Parameter Optimization Based on Orthogonal Design[J];Journal of Projectiles,Rockets,Missiles and Guidance;2008-05
9 LIAO Su-Mei HUANG Qing-Hua LIN Lin MO Yun-Yan (Department of Analytical Chemistry,Guangdong College of Pharmacy,Guangzhou 510006,China);Optimization of extraction procedure of polysaccharide in tangerine peel[J];Journal of Guangdong College of Pharmacy;2007-06
10 WANG Xiao-yu,BAI Dan,LI Zhan-bin,LI Gang(Key Lab of Northwest Water Resources and Environment Ecology,Ministry of Education,Xi'an University of Technology,Xi'an,Shaanxi 710048,China);Analysis on influence factors of subsurface drip irrigation emitter discharge under silt loam soil condition[J];Agricultural Research in the Arid Areas;2009-01
China Proceedings of conference Full-text Database 4 Hits
1 Han Xi Wu Jiming Feng Hongnian Xie Jinchun;Applying Near Infrared Spectroscopy to real-time monitoring the producing process of Nitrotoluene[A];[C];2008
2 CHEN Yuguang~(1,2) Lin Tao~1 LIAO Shili~1 YOU Shihai~2 (1)Chongqing Institute of Technology,Chongqing 400050 (2)The Key Lab of Automobile Parts& Test Technique in Chongqing,Chongqing 400050;The optimization of OBDⅡfault dictionary based on fuzzy orthogonal test[A];[C];2008
3 Liang Jun~1 Xu Jin-song~1 Xie Jie~1 Yang Xiao-yu~2 1 School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiao Tong University,Shanghai 200030; 2 Shanghai Karmon Technology Co.,Ltd.,shanghai 200235;The Hull Lines Automatic Optimization Based on Design Space Exploration[A];[C];2008
4 Jin Baigang~(1,2) Wang Jun~1 Chen Ming~1 Wang Qiang~2 Wang Jinhui~1 Li Lixun~1 He Jicheng~2 (1.Ansteel Bayuquan Iron and Steel Subsidiary Steel-making Department,Yingkou,115007; 2.Key Laboratory of Electromagnetic Processing of Materials,Northeastern University,Shenyang,110004 );Application of Electromagnetic Stirring in Ansteel Slab Continuous Caster[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHENG Lei WANG Qian WEI Kuan-hai Pei Guo-xian (Department of Orthopedics and Traumatology. Clinical Laboratory Nanfang Hospital, First Military Medical University. Guangzhou 510515. China);Biological effects of basic fibroblast growth factor on bone marrow stromal cells[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved