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《Chemical Reagents》 2006-07
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The synthesis of N,N′-bismethyl-N,N′-bis-(2,3,4,5,6-pentahydroxyhexyl)-2,3,5,6-tetraiodoterephthalamide

ZHANG Lai-guo 1,2,LUO Shi-neng *1,2,LIU Xiao-ya1,XIE Min-hao2,ZOU Pei2,LIU Ya-ling2,HE Yong-jun2 (1.School of Chemical and Material Engineering,South Yangtze University,Wuxi 214036,China;2.Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China)  
N,N′-Bismethyl-N,N′-bis-(2,3,4,5,6-pentahydroxyhexyl)-2,3,5,6-tetraiodoterephthal-amide is synthesized by iodination of terephthalic acid,acyl chloride and amdiation.Their structures were identified by elemental analysis,IR,MS and 1HNMR.Under the optimal reaction conditions triethylamine∶tetraiodoisophthalic acid dichloride∶N-methylglucamine=2.1∶1∶2.4,reaction temperature is 40℃,the yield is 71.5%.
【CateGory Index】: O625.53
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LUO Shi-Neng; XIE Min-Hao; XI Yue-Fen; ZHANG Man-Da;MENG Hong; LIU Ya-Ling; HUANG He-Yun; ZOU Pei(State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063);SYNTHESIS OF NON-IONIC X-CT CONTRAST MEDIUM IOHEXOL[J];CHINESE JOURNAL OF PHARMACEUTICALS;1995-10
2 LUO Shi-neng,ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun, YANG Zheng (Jiangsu Institute of Nuclear Medicine , Wuxi 214063, China );Synthesis of ioversol,a non-ionic x-ray contrast agent[J];Chinese New Drugs Journal;2004-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Ya ling, LUO Shi neng, XIE Min hao, HE Yong jun, ZOU Pei, YANG Zheng (Jiangsu Institute of Nuclear Medicine, Jiangsu Wuxi 214063, China);Synthesis of 5-(β-Hydroxyl-α-naphthalene azo)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide and Its Application[J];Huaxue Shijie (Chemical World);2003-05
2 LUO Shi neng 1,2 SHEN Yong jia 1, XIE Min hao 2, LIU Ya ling 2, ZOU Pei 2, HE Yong jun 2 (1.East China University of Science and Technology, Shanghai 200237, China; 2.Jiangsu Institute of Nuclear Medicine, Jiangsu Wuxi, 214063, Chin;Study on Viscosity of Non-ionic X-ray Contrast Agents[J];Huaxue Shijie (Chemical World);2002-08
3 ZHANG Lai-guo1,2,LUO Shi-neng2,1*,XIE Min-hao2,LIU Xiao-ya1,ZOU Pei2,LIU Ya-ling2,HE Yong-jun2 (1.School of Chemical and Materials Engineering,Southen Yangtze University,Wuxi 214122,China;2.Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);Synthesis of N,N′-Bis(Dihydroxypropxyl)-2,3,5,6-Tetraiodoterephthalamide[J];Journal of Southern Yangtze University (Natural Science Edition);2007-01
4 Xie Heqing,Li Jingfen (Faulty of Life Science Huzhou Teachers College Huzhou 313000 );Improvement of Synthesis Techics of Medical Intermediat 17α-Hydroxy-21-iodopregn Progesterone[J];China Chemicals;2008-05
5 Xie Heqing,et al(Faulty of Life Science,Huzhou Teachers College,Huzhou 313000);Orthogonal Experimental Design in 17α-hydroxy-21-iodine Progesterone Improved Synthesis of the Application[J];Journal of Mathematical Medicine;2008-05
6 LUO Shi Neng 1,2 , SHEN Yong Jia 1 , XIE Min Hao 2 , LIU Ya Ling 2 , ZOU Pei 2 (1. Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237; 2. Jiangsu Institute of Nuclear Medicine, Wuxi 214063);Improved Synthesis of Iohexol[J];Chinese Journal of Pharmaceuticals;2003-06
7 LIU Ya-ling1,LUO Shi-neng1, ZOU Pei1,XIE Min-hao1, HE Yon g-jun1,WANG De-hang2, PAN Xi-jian2(1.Jiangsu Institu te of Nuclear Medicine, Wuxi 214063,China; 2.First affiliated Hospital of Nanji ng Medical University, Nanjing 210029,China);Preparation and CT contrast enhancement in animals of X-ray contrast agent Ioversol injection[J];The Chinese Journal of Modern Applied Pharmacy;2005-02
8 ZOU Pei1,2,LUO Shi-neng1,LIU Ya-ling1,XIE Min-hao1,HE Yong-jun1,SHEN Yong-jia2(1 Jiangsu Institute of Nuclear Medicine,WuXi 214063,China;2 Institute of Fine Chemicals,East China University of Science and Technology,Shanghai 200237,China);HPLC determination of ioversol[J];Chinese Journal of New Drugs;2004-S1
9 Zhou Pel ( Zhou P ), Luo Shineng ( Luo SN ), Xie Minghao ( Xie MH), et al ( Jiangsu Institute of Nuclear Medicine , State Key Laboratory of Nuclear Medicine , Wwd 214063);Synthesis of 3,5-bis[acetyl(2,3-dihydroxypropyl) amino]-N-(2-hydroxyethyl)-2,4,6-triiodo-benzamide[J];Chinese Journal of Modern Applied Pharmacy;1998-03
10 ZOU Pei~1, LUO Shi-neng~1, WANG Lin-xiang~2, LIU Ya-ling~1, XIE Min-hao~1, HE Yong-jun~1(1 Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China; 2 Centre of Analysis, Southern Yangtze University, Wuxi 214036, China);Determination of residual solvents in ioversol by head space-gas chromatography[J];Chinese New Drugs Journal;2005-02
China Proceedings of conference Full-text Database 1 Hits
1 ;The development of iodinated X-ray contrast agents[A];[C];2004
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