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《Chemical Reagents》 2010-12
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New process for synthesis of 3,5-diiodo-L-tyrosine

ZHANG Wen-wen1,CHEN Hui-ru1,LUO Fang2,CHEN Sheng-jun2,CHEN Wen-qi1,JI Min2(1.Department of Pharmaceutical Technology and Biological Engineering,Changzhou Institute of Engineering Technology,Changzhou 213164,China;2.College of Chemistry and Chemical Engineering,Southeast University,Nanjing 210096,China)  
3,5-Diiodo-L-tyrosine was prepared via iodization of iodine monochloride.Experimental results showed that the optimal conditions for iodization of iodine monochloride were as follows:the volume ratio of acetic acid solvent to iodine monochloride was 8∶1,the mole ratio of iodine monochloride to L-tyrosine was 3.6∶1,and the reaction temperature was 60 ℃.Under the optimal reaction conditions,the yield of 3,5-diiodo-L-tyrosine could reach up to 90%.The product structure was confirmed by 1HNMR spectroscopy.
【Fund】: 常州市工业科技攻关项目(CE20090019)
【CateGory Index】: TQ463.2
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 DONG Yan,LEI Peng,HU Zhi-zhi(School of Chemical Engineering,University of Science and Technology Liaoning,Anshan 114051,China);New technique on iodination of substituted anilines[J];Journal of University of Science and Technology Liaoning;2009-03
2 ZHANG Ying(1,2),ZHANG Feng2,ZHANG Xiang-dong2,(1.Department of Chemical Science and Engineering,Liaoning University,Shenyang 110036,China;2.Department of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China);The Synthesis of 3,5-dimethyl-DL-tyrosine[J];Journal of Liaoning University(Natural Sciences Edition);2007-01
3 YIN Qi shan, JIANG Bo kang, MAO Zi qi, SUN Xiong ping, WANG Yue jia (Shanghai Research Institute of Fine Chemical & Technology, Shanghai 201612, China);Synthesis of L-Thyroxine[J];Huaxue Shijie (Chemical World);2001-01
4 HOU Fu-hui,GAO Zhi-xin,LIU Min-xian,L Jiu-an,XU You-jun(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,china);Syntheses of thyronamines—analogues of thyronine[J];Chinese Journal of Medicinal Chemistry;2007-06
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Ying*1,2,ZHANG Feng1,ZHANG Xiang-dong1 (1.School of Chemical Science and Engineering,Liaoning University,Shenyang 110036;2.School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016);Determination of Dissociation Characteristics of 3,5-Dimethyl-DL-tyrosine and 3,5-Diiodo-DL-tyrosine by Potential Titration Method[J];Journal of Analytical Science;2007-06
2 WANG Peng1,WANG Zhong-wei2,ZHANG Qing-long1,ZHUANG Hua-hong1,KOU Xiao-yan1(1 College of Chemical and Environmental Engineering,Shandong University of Science and Technology,Shandong Qingdao 266510;2 College of Materials Science and Engineering,Shandong University of Science and Technology,Shandong Qingdao 266510,China);Synthesis of 2,6-Diiodo-4-Methylaniline[J];Guangzhou Chemical Industry;2011-04
3 ZHANG Ying1,2,ZHANG Feng1,ZHANG Xiang-dong1(1.The School of Chemical Science and Engineering,Liao Ning University,Shenyang 110036,China;2.The School of Pharmaceutical Engineering,Shen Yang Pharmaceutical University,Shenyang 110016,China);Stability research of 3,5-dimethyl-D,L-tyrosine and corresponding binary complexes of of Cu(Ⅱ) and aromatic diamine[J];Chemical Research and Application;2009-05
4 ZHANG Wen-wen1,CHEN Hui-ru1,JI Min2(1.Department of Pharmaceutical Technology and Biological Engineering,Changzhou Institute of Engineering Technology,Changzhou 213164,China;2.College of Chemistry and Chemical Engineering,Southeast University,Nanjing 210096,China),;Research progress in the synthesis of L-thyroxine[J];Chemical Reagents;2010-11
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 ZHAI Mu-heng, ZHANG Nian-rong, ZHANG De-xin, SHAN Yong-jia, SHENG Liang-jun (College of Chemistry and Materials Science, Anhui, Normal University, Wuhu 241000, China);SYNTHESIS AND CHARACTERIZATION OF 3,5-二-(N-ACETAMINO)-2,4,6-TRIIODOBENZOYL CHLORIDE[J];Journal of Anhui Normal University(Natural Science);2004-02
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