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《Chemical Reagents》 2011-03
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Synthesis and structure of diorganotin pridinecarboxylates containing silicon

LIN Sen~a,DENG Jian-yang~a,JIANG Yu-chun~a,DENG Rui-hong~a,JIE Ke-min~b,GAO Ming~a(Nanchang University,a.Department of Chemistry;b.Medical College,Nanchang 330031,China)  
Seven diorganotin pridinecarboxylates containing silicon were synthesized by the reaction of diorganotin oxides with pridinecarboxylic acids.The structures were affirme via IR,1HNMR,13CNMR,elemental analysis.The preliminary bioassay tests showed that the compound Cy(Me3SiCH2)Sn-(OCOC5H4N-o)2 exhibited a good antitumour activity in vitro against lung tumour cells A549 and colorectal tumour cell SW480.
【Fund】: 国家自然科学基金资助项目(20762006);; 江西省自然科学基金资助项目(2007JZH2103)
【CateGory Index】: O627.42
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