Synthesis of 5-(β-Hydroxyl-α-naphthalene azo)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide and Its Application
LIU Ya ling, LUO Shi neng, XIE Min hao, HE Yong jun, ZOU Pei, YANG Zheng (Jiangsu Institute of Nuclear Medicine, Jiangsu Wuxi 214063, China)
5-(β-Hydroxyl α naphthalene diazo) N,N' bis(2,3 dihydroxypropyl) 2,4,6 triiodoisophthalamide was synthesized by two steps. Firstly, 5 diazo N,N' bis(2,3 dihydroxypropyl) 2,4,6 triiodoisophthalamide chloride was prepared by diazotization of 5 amino N,N' bis(2,3 dihydroxypropyl) 2,4,6 triiodoisophthalamide. Secondly, 5 diazo N,N' bis(2,3 dihydroxypropyl) 2,4,6 triiodoisophthalamide chloride reacted with β naphthol to form 5 ( β hydroxyl α naphthalene azo) N,N' bis(2,3 dihydroxypropyl) 2,4,6 triiodoisophthalic acid amide. The structure of the product was confirmed by elemental analysis, IR, 1H NMR and FAB MS. The UV spectrum of the product showed a maximum at 450nm and an ε max of 1.2×10 4. The linearity of the absorption curve was fairly good in the range of(0.58×10 -6 mol/L~58.1×10 -6 mol/L). This method can be used in determining the impurity in Ioversol.
【CateGory Index】： O625