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《Huaxue Shijie (Chemical World)》 2003-08
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Study on the Synthesis of Fasciolicide Nitroxynil

ZHAO Hai shuang, ZHOU Le, GENG Hui ling (College of Life Sciences, Northwest Science and Technology University of Agriculture and Forestry, Shaanxi Yangling 712100, China)  
Nitroxynil was prepared from p hydroxybenzaldehyde by cyanation, nitration and iodination reactions. Firstly, p hydroxybenzonitrile was obtained in 88.6% yield by the reaction of p hydroxyben zaldehyde with hydroxylamine hydrochloride and sodium formate in formic acid; secondly, p hydroxyben zonitrile reacted with nitric acid in glacial acetic acid to give 92.9% 4 hydroxy 3 nitrobenzonitrile; and thirdly, the latter was iodinated directly with iodine in the presence of hydrogen peroxide to yield 93.9% nitroxynil(77.3% based on p hydroxybenzaldehyde). The structures of the intermediates and the title compound were identified with IR, MS and elemental analysis. The results showed that the method had a feature of lower cost and higher yield.
【CateGory Index】: O625.67
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