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《Chemistry》 2012-01
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Synthesis of 2-Vinyl-8-hydroxyquinolin Derivatives and Their Antioxidation Activities

Zhang Peiquan1,Zeng Heping2,Zhang Weimin2(1Laboratory Center of Pharmaceutical Sciences,Guangzhou Medical College,Guangzhou 510182;2Institute of Functional Molecules,Faculty of Chemistry,South China University of Technology,Guangzhou 510641)  
2-(2-(9H-fluoren-2-yl)vinyl)-8-hydroxyquinoline(6) and 2-(2-(phenanthren-9-yl)vinyl)-8-hydroxyquinoline(7) have been synthesized.The structure of compounds 6 and 7 were confirmed by UV-Vis,FT-IR,ESI-MS,1HNMR and elemental analysis.Meanwhile,the antioxidation activities of the titled compounds have been investigated by the DPPH·,O-·2 and OH·methods.The results showed that the titled compounds have strong antioxidation activity to the DPPH·,O-·2 and OH· free radicals.
【Fund】: 国家自然科学基金项目(20671036);; 广东省科技项目(2006A10801002);; 广州医学院青年基金项目(L95115)资助
【CateGory Index】: R914
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