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《Acta Chimica Sinica》 1980-06
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STUDIES ON THE ANTITUMOR CONSTITUENTS OF ZANTHOXYLUM NITIDUM (ROXB.) DC.

HUANG ZHI-XUN LI ZHI-HE (Guangxi Institute of Medical and Pharmaceutical Science, Nanning)  
Seven alkaloids were isolated from the roots of Zanthoxylum nitidum (Roxb.) DC and six of them were identified as nitidine chloride (1), oxynitidine (2), dihydronitidine (3), 6-methoxy-5, 6-dihydrochelerythrine (4), α-allocryptopine (5) and skimmianine (6). The structural study on 7 is in progress.1 and 4 were able to increase the life span of mice inoculated with Ehrlieh's ascites tumor, while 2, 3, 5 and 6 were inactive. 1 was effective in the treatment of chronic myelocytic leukemia.
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