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《Acta Chimica Sinica》 1987-03
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Studies on the Chemical Constituents of Ilex pubescens Hook et Am II. The Structure of Ilexsaponin A

Qin Guo-Wei Chen Zheng-Xiong Xu Ren-Sheng(Shanghai Institute of Materia Medica, Academia Sinica, Shanghai)Jiang Zhong-Fang Liang Jing-Guo(Guangzhou Institute of Pharmaceutical Industry, Guangzhou)  
A new saponin, named Ilexsaponin A, was isolated from the roots of Ilex pubescens Hook et Am. Its structural elusidation is reported.Ilexsaponin A (1), white needles, C_(36)H_(56)O_(11), m. p. 285-287℃(dec), [α]_D~(11)+39.2°,has positive to Liebermann-Burchard test. By hydrolysis with 5% H_2SO-4-EtOH, 1 afforded glucose and genuine saponin 2, C_(30)H_(46)O_5, which was converted to several derivatives (5-7 and 13-14). When 1 was hydrolyses with 2% HCl-MeOH, three artefact sapogenins (8,10, and 12) were formed, which were also converted to several derivatives. The structure of 1 was shown to be 3β, 19a-dihydroxy-urs-12-ene-24, 28-dioio acid-28-β-D-glucopyranosyl ester by the above chemical conversions and spectral analysis of ~(13)C NMR, ~1H NME, MS, IE and UV. 2 is a new 19α-hydroxy-ursane sapogenin.
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