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《Acta Chimica Sinica》 1997-08
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Fluorimetry Used for Preliminary Screening of Eleven Novel Palladium Complexes as Potential Antitumour Agents

LI Zhi - Liang BI Qiong - Si LI Jun - Zheng LIN Hui - Xiang YU Ru - Qin(Department of Chemistry and Chemical Engineering, Hunan University, Changsha ,410082) ( Institute of Chemometrics and Pharmacy, Hunan University, Changsha, 410082)  
A novel fluorimetric method has been developed as a new in vitro method for preliminary screening of metallic complexes as potential antitumour or anticancer agents and for further approach of action mechanism using ethidium bromide as a fluorescent probe. This method was used for in vitro testing and screening eleven new complexes of palladium(II)/ligand, as potential agents, using diamine/lysine or diamine/nitrate as the mixed ligands. The fluorimetric screening method was compared with methylene blue test and MTT dye - exclusion assay. All three methods gave agreeable results. The antineoplastic ratios and binding constants with DNA were obtained by animal test, by MTT method and by fluorimetric screening.
【Fund】: 国家教委、机械部及国家自然科学基金资助课题
【CateGory Index】: O657.3
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Chinese Journal Full-text Database 9 Hits
1 LIU Xiao-yu(Biochemical Engineering College of Beijing Union University,Beijing 100023, China);Research On Interaction Between Complexes of Y-cydta,Y-dtpa and DNA[J];Journal of Beijing Union University(Natural Sciences);2009-01
2 Li Yuanfang; Huang Chengzhi; Hu Xiaoli (Institute of Environmental Chemistry, Southwest Nounal University, Chongqing 400715);The Principles and the Applications of Resonance Light Scattering Technique in the Research of Biochemistry and Bioanalysis[J];Chinese Journal of Analytieal Chemistry;1998-12
3 SHANG Dan, ZHANG Chao-ping(Department of Chemistry , Guizhuo University, Guiyang 550025,China);The Research Status of Metal Anticancer Drug[J];Journal of Guizhou University(Natural Science);2005-01
4 WANG Hai-yan1,HUANG Ji-zhen2 (1. College of Life Science,Anhui Agricultural University,Hefei 230036,China; 2.Key Laboratory of Tea Biotechnology & Biotechnology,Ministry of Agriculture,Ministry of Education,Hefei 230036,China);Study on the interaction of Kudingcha and DNA by the fluorescence method[J];Science and Technology of Food Industry;2010-07
5 WANG Hai-yan1,HUANG Ji-zhen2(1.College of Life Science,Anhui Agricultral University,Hefei 230036;2.Key Laboratory of Tea Biochemistry & Biotechnology,Ministry of Agriculture,Ministry of Education,Hefei 230036);Study on the interaction of Gaocha solution,Gaocha phenols and DNA with the fluorescence method[J];Food Science and Technology;2010-08
6 HU Wen-yu~1,YI Yan-ping~2,YING Hui-fang~3,MEI Guangquan~2(Yichun University,Yichun 336000,China);Recent research advance of non-platinum-group precious metal complexes in the field of medicine[J];Studies of Trace Elements and Health;2006-05
7 FEI Dan1,WANG Xing-ming1,RUAN Kai-min1,ZHANG Jingjing1,LIU Sheng-nan1,ZHANG yi-qian1,DING Li-sheng2 (1.School of Material Science and Technology,Southwest University of Science and Technology,Mianyang 621010,Sichuan,China;2.Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,Sichuan,China);The Interaction between Gd(Ⅲ)(ARS)_3 and DNA[J];Journal of Southwest University of Science and Technology;2008-01
8 PAN Hai-zhuan1,WANG Xing-ming1,FEI Dan1,DAI Ya-tang1,SHANG Shao-ping1,ZHAO Ting-ting1,DING Li-sheng2(1.School of Materials Science and Engineering,Southwest University of Science and Technology,Mianyang 621010,Sichuan,China;2.Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,Sichuan,China);Study on the Interaction Mode between the Er(Ⅲ)(HE)_3 and DNA by Spectrometry[J];Journal of Southwest University of Science and Technology;2010-01
9 Yuan Xiaoling, Zeng Jingping, Mei Guangquan* (School of Science, Yichun University, Yichun 336000, China);Application of Precious Metal Complexes to Medicine[J];Chinese Journal of Rare Metals;2005-04
China Proceedings of conference Full-text Database 1 Hits
1 Mei Guang-Quan Huang Ke-Long (College of Chemistry and Chemical Engineering, Central South University, Changsha 410083 Hunan) (School of Science, Yichun University, Yichun 336000 Jiangxi);Application of the Precious Metal Complexes to the Medicine[A];[C];2005
Chinese Journal Full-text Database 1 Hits
1 Bi Qiongsi Li Junzhong Li Wansan Lin Huixiang (Department of Chemistry and Chemical Engineering , Hunnan Univ ,Changsha , 410082);A Study of New-Model Antitumor Complexes Ⅳ :Synthesis, Characterizatin and Antitumor Activity Studies of Some [Pd(diamine)(NO_3)_2] Complexes[J];JOURNAL OF HUNAN UNIVERSITY(NATURNAL SCIENCES);1994-05
Chinese Journal Full-text Database 10 Hits
1 LIU Si-yuan et al(College of Life Sciences,Nantong University,Nantong,Jiangsu 226007);Study on the Inclusion Complex of Cyclovirobuxine D and Hydroxypropyl-β-cyclodextrin[J];Journal of Anhui Agricultural Sciences;2008-35
2 XIA Chuanjun,ZHANG Li,ZHANG Rui,ZHAO GuangChao(College of Environmental Science, Anhui Normal University, Wuhu 241000, China);INTERACTION OF NANO-SILVER COLLOID WITH BOVINE SERUM ALBUMIN AND ITS APPLICATION[J];Journal of Anhui Normal University(Natural Science);2003-02
3 LONG Miao-Yun,LI Hong-Hao,XU Jun-Yao,LAI Dong-Min,WENG Zhen-HONG Department of General Surgery,The Second Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,510120,P.R.China;Inhibitory Effects of Transfection of Arresten Gene on Liver Metastasis from Colorectal Cancer in Nude Mice[J];Chinese Journal of Cancer;2008-10
4 Dong-Xia Yang1,Nai-E Li2,Yun Ma1,Yan-Chun Han1,Yan Shi31. Department of Pathology,Binzhou Medical College,Yantai,Shandong 264003,P.R. China2. Department of Diagnostics,Binzhou Medical College,Yantai,Shandong 264003,P.R. China3. Department of Histology and Embryology,Binzhou Medical College,Yantai,Shandong 264003,P.R. China;Expression of Elf-1 and survivin in non-small cell lung cancer and their relationship to intratumoral microvessel density[J];Chinese Journal of Cancer;2010-04
5 Wang Guangbin(Department of C heniistry, Xianyang Teachers College);Antibacterial Activity of Cu (Ⅱ)、Zn (Ⅱ) Complexes with Schiff BaSe of DL-Methionine[J];;1994-01
6 ZHOU Yagin, GUO Bo, CAO Enhua, SONG Zengfu, ZHOU Shiwu, QIN Yuan, ZHA Renjun(Department of Physics, Peking University) (Biology Institute, Chinese Academy of Sciences);Study on the Interaction of Chinese Herbal Medicine (CHM) and DNA by Florescence EB Probe[J];Acta Scicentiarum Naturalum Universitis Pekinesis;1993-01
7 Dong Wenyan; Zheng Ying; Liu Xiaobing;Chen Guiqin(College of Sciences and Humanities of BUU,100083)[;Effect of Kudingcha on Hypelipidemia in Mice[J];JOURNAL OF BEIJING UNION UNIVERSITY;1994-01
8 WANGShan ,CHENGJi jian ,CHENQi (ResearchInstituteofInorganicMaterials,EastChinaUniversityofScience andTechnology ,Shanghai 2 0 0 2 37,China);The Research and Applications of the Ag -Type Soluble Glass Antibacterial Agents[J];GLASS & ENAMEL;2000-05
9 CHANG Xiao yu, LIU Yun, ZHANG Jun, SUN Yu e (College of Chemical Engineering, Beijing Technology and Business University, Beijing 100037, China);RESEARCH FOR SYNTHESIS OF PORPHYRIN CATION[J];Journal of Beijing Institute of Light Indusry;2002-01
10 Liu Yun\ Xu Tongkuan\ Xiao Debao\ Zhang Jun\ Sun Y e (Department of Chemical Engineering, Beijing Institute of Light Industry, Beijing 100037);SYNTHESIS OF MESOTETHAPHENYLPORPHYRINS\=(TPP) BY CATALYST IN SOLVENTS AND \=UNDER MICROWAVE IRRADATION[J];Journal of Beijing Institute of Light Indusry;1998-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Zhang Haiying,Qi Rongrong,Tong Mingkang(School of Chemistry and Chemical Engineering,Shanghai Jiaotong University,Shanghai 200240,China);PREPARATION AND CHARACTERIZATION OF ULTRAVIOLET RESISTANCE OF EPOXY/ZnS NANOCOMPOSITES[J];Engineering Plastics Application;2010-09
2 FAN Jiu-liang,WANG Yu-mei,ZHOU Shuang-sheng (School of Pharmacy,Anhui University of Traditional Chinese Medicine,Hefei 20031 China);Studies on Synthesis and DNA-binding Interaction of Platinum(Ⅱ) Complex of Curcumin Analog[J];Journal of Hefei Normal University;2010-03
3 LIANG Rong-yuan(Xiamen Municipal Environmental Monitoring Station,Xiamen 361004);Determination of Mercury Using Resonance Light-scattering Method[J];Environmental Science & Technology;2006-03
4 WANG Liuping 1 JIANG Zhiliang 2 1(Liuzhou Railway Transport school\ Liuzhou\ 545000) \ \+2(The Chllege of Chemistry and Life Science, Guangxi Noirmal University\ Guilin\ 541004);Study on Resonance Scattering Spectroscopy for the Photochemical Reaction of Silver(Ⅰ) and Benzoglycolic Acid[J];ANALYSIS AND TESTING TECHNOLOGY AND INSTRUMENTS;2000-01
5 JIANG Zhi liang, LI Fang, LIANG hong (The College of Chemistry and Life Science, Guangxi Normal University, Guilin 541004, China);Surface-enhanced Resonance Scattering Spectroscopic Study of Ag-CV System[J];ANALYSIS AND TESTING TECHNOLOGY AND INSTRUMENTS;2000-02
6 LIU Qing ye, JIANG Zhi liang, MENG Mian wu (Institute of Material Science and Engineering, Guangxi Normal University, Guilin 541004, China);Microwave High-pressure Synthesis of Pd Nanoparticle and Its Spectral Properties[J];Analysis and Testing Technology and Instruments;2001-04
7 ZOU Cai xia\+1, JIANG Zhi liang\+2, YIN Wen qing\+2 (1. City Construction School of Guangxi, Guilin 54100, China; 2. Department of Resource and Environmental Science, Guangxi Normal University, Guilin 541004, China);Studies on the Hypochromic Effect of Composite Nanoparticle of Toluidine Blue-Sodium Tetrabenboron[J];Analysis and Testing Technology and Instruments;2002-02
8 LI Fang, JIANG Zhi-liang (Department of Resource and Environmental Science, Guangxi Normal University, Guilin 541004; China);Resonance Scattering and Fluorescence Quenching and Hypochromic Effects of (PtI_6-2RDG)_n Association Nanoparticle[J];Analysis and Testing Technology and Instruments;2002-03
9 Liao Zuhe, Luo Yanghe, Jiang Zhiliang, Xie Jiyun(Department of Resource and Environmental Science, Guangxi Normal University, Guilin541004, China);Resonance Scattering Spectroscopic Study of Colibacillus[J];Analysis and Testing Technology and Instruments;2003-02
10 CHENG Yun-yan, LUO Yang-he, JIANG Zhi-liang (Department of Resource and Environmental Science, Guangxi Normal University, Guilin 541004, China);Spectral Properties of Cationic Surfactant-I~-_3 Association Particle System and Its Analytical Application[J];Analysis and Testing Technology and Instruments;2005-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Bi Qiongse Peng Hua Lin Huixiang Chen Zhengyu Department of Chemistry and Chemical Engineering;A Study of New Model Antitumor Complexes——Complexes of pd(Ⅱ)-Dextran-Bidentate Amine as Antitumor Agent[J];Journal of Hunan University (Natural Science);1992-06
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