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《Acta Chimica Sinica》 2005-21
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Radiolabeled Synthesis and Identification of a Novel Herbicide, Pro-pyl4-[2-(4,6-Dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with All Six Benzoic Ring Carbons Labeled by ~(14)C

YANG, Zheng-Mina,c YE, Qing-Fub TANG, Qing-Hongc LU, Long*,c CHEN, Zi-Yuanb (a College of Life Science, Northwest Science and Technology University of Agriculture and Forestry, Xianyang 712100) (b Institute of Nuclear-Agricultural Science, Zhejiang University, Hangzhou 310029) (c Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)  
A radiochemical, propyl 4-[2-(4,6-dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with all six benzoic ring carbons labeled by 14C was made from 4-aminobenzoic acid with all six benzoic ring car-bons labeled by 14C through esterification, condensation, reduction and substitution, and purified by prepara-tive HPLC. Its structure was identified by LC-MS and 1H NMR. HPLC test showed its chemical purity ex-ceeded 98%. HPLC-LSC and TLC-IIA demonstrated that its radiochemical purity exceeded 98% and spe-cific activity was 1.089±0.011 mCi/mmol. The total chemical yield and radiochemical yield were all 53%.
【Fund】: 973课题“绿色化学农药先导结构及作用靶标的发现与研究”(No.2003CB114406)资助项目.
【CateGory Index】: TQ457;
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1 WANG Wei~1 YUE Ling~1 DING Wei~1 YU Zhi-yang~1 WANG Hai-yan~1 YE Qing-fu~(1) LU Long~2(1.Institute of Nuclear-Agricultural Science,Zhejiang University,Hangzhou,Zhejiang 310029;2.Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032);LEACHING AND MOVEMENT OF [A ring-U-~(14)C] PYRIBAMBENZ-PROPYL IN SOIL[J];Journal of Nuclear Agricultural Sciences;2007-03
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