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《Acta Chimica Sinica》 2008-04
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Synthesis, Radiosynthesis and Anticancer Activity of β-Elemene Tricarbonyl Rhenium Complex

REN, Yun-Fenga,b CHENG, Kang-Mina,b LIU, Gui-Fenga,b SUN, Yan-Honga SHEN, Yu-Mei,a (a Radiopharmaceutical Centre, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800) (b Graduate School of the Chinese Academy of Sciences, Beijing 100049)  
Starting from the Traditional Chinese Medicine β-elemene, a new kind of β-elemene tricarbonyl rhenium complex was prepared via halogenation and nucleophilic substitution reactions, followed by reaction with tricarbonyl rhenium. Under the similar reaction conditions, the radioactive β-elemene tricarbonyl rhenium complex was synthesized. All the compounds were characterized by IR, 1H NMR, HRMS, HPLC or elemental analysis. The anticancer activity of the target compound was observed in Hela and LLC lines in vitro. The β-elemene tricarbonyl rhenium complex provides the possibility to explore the anticancer mechanism of β-elemene and furthermore find a new kind of radiopharmaceuticals on basis of β-elemene.
【Fund】: 中国科学院“百人计划”(No.26200601)资助项目
【CateGory Index】: O641.4;R730.5
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