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《Chemical Research》 2007-03
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Synthesis and Thermosensitive Characterization of DTPA-Poly(N-isopropylacrylamide)

JIANG Shu-bin*,WANG He-yi,ZHONG Zhi-jing,YANG Yong(Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,P.O.Box 919—215,Mianyang 621900,Sichuan,China)  
The thermosensitive poly(N-isopropylacrylamide)(PNIPAAm) aqueous solutions behave the low critical solution temperature(LCST) and could be used as drug delivery system.A novel drug delivery system based on PNIPAAm with isotopically labellable end groups DTPA has been designed and synthesized by reaction of 4,4′-azobis(4-cyanopentanoic acid),N-isopropylacrylamide,diethylenetriaminepentaacetic dianhydride and ethylenediamine.DSC measurements indicated DTPA-PNIPAAm showed similar LCST to that of PNIPAAm.DTPA-PNIPAAm enabled the delivery of therapeutic nuclides by PNIPAAm.
【Fund】: 中国工程物理研究院科学基金项目(20060537)
【CateGory Index】: O633.22
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