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《Chemical Research》 2007-03
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Studies on the Chemical Constituents of Gliotoxins Produced by Marine-derived Aspergillus Fumigatus

ZHAO Wen-ying1,2,GU Qian-qun1*,ZHU Wei-ming1(1.Key Laboratory of Marine Drugs of MEC & SP,Ocean University of China,Qingdao 266003,Shandong,China;2.Qingdao University of Science and Technology,Qingdao 266042,Shandong,China)  
In order to find bioactive compounds from marine microorganisms,the secondary metabolites of the fermentation of aspergillus fumigatus were studied.Four compounds were isolated from the active extract by chromatography on silica gel,sephadex LH-20 column and HPLC,respectively.Their structure were identified on the basis of comparison to literature and spectroscopic analysis as gliotoxin(1),bisdethiobis(methylthio)gliotoxin(2),didehydrobisdethio-bis(methylthio)gliotoxin(3)and bis-N-norgliovictin(4).Compound(1) exhibited very strong cytotoxicity against tsFT 210 cell line at 0.15 mg/L.
【Fund】: 山东省自然科学重点基金资助项目(Z2006C13);; 中澳国际合作项目(2005DFA30030-4)
【CateGory Index】: Q936
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