Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chemical Research》 2007-03
Add to Favorite Get Latest Update

Studies on the Chemical Constituents of Gliotoxins Produced by Marine-derived Aspergillus Fumigatus

ZHAO Wen-ying1,2,GU Qian-qun1*,ZHU Wei-ming1(1.Key Laboratory of Marine Drugs of MEC & SP,Ocean University of China,Qingdao 266003,Shandong,China;2.Qingdao University of Science and Technology,Qingdao 266042,Shandong,China)  
In order to find bioactive compounds from marine microorganisms,the secondary metabolites of the fermentation of aspergillus fumigatus were studied.Four compounds were isolated from the active extract by chromatography on silica gel,sephadex LH-20 column and HPLC,respectively.Their structure were identified on the basis of comparison to literature and spectroscopic analysis as gliotoxin(1),bisdethiobis(methylthio)gliotoxin(2),didehydrobisdethio-bis(methylthio)gliotoxin(3)and bis-N-norgliovictin(4).Compound(1) exhibited very strong cytotoxicity against tsFT 210 cell line at 0.15 mg/L.
【Fund】: 山东省自然科学重点基金资助项目(Z2006C13);; 中澳国际合作项目(2005DFA30030-4)
【CateGory Index】: Q936
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 YANG Zi-juan1,2,XIANG Lan1,XING Jie1,ZHENG Yi-nan2(1. School of Pharmacy,Shandong University,Jinan 250012,China;2. School of Chinese Material Medica,Jilin Agricultural University,Changchun 130118,China);Research advances in cyclic dipeptides[J];Modern Pharmacy and Clinic;2009-02
2 XUE Duo-Qing1,Wang Jun-Jie2,LIU Hai-Li1,GUO Yue-Wei1 State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China Hainan Sanya National Coral Reef Natural Reserve Administration,Sanya 572100,China;Recent Progress of Marine Natural Products Research in China[J];Chinese Journal of Natural Medicines;2009-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LONG Xue-ming,YOU Si-xiang,LIU Xiang-xin,FU Ya-xiang(College of Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan,410128,China);Antibacterial Effect in vitro of the Extract from Hemistepta Lyrata Bunge[J];Progress in Veterinary Medicine;2007-11
2 Zhong Xiaoming1,Mao Qingqiu1,Huang Zhen1,et al 1.Department of Pharmacy,Zhejiang University of Tradition Chinese Medicine,Hangzhou (310053);Study on the Antidepressant Effects and Mechanism of Hypericum Perforatum L.(EHP)in Stress-induced Depressive Model[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-02
3 DONG Yan-min~1,LI Hui-ling~1,NI Qing~2(1.Chinese Medical Hospital of Shenzhen;Guang Anmen Hospital of Traditonal Medical Academy 518033);Mechanisms of Acupuncture with Supplement Qi and Yin and Activating Blood Circulation on Diabetic rats with Peripheral Neuropathy[J];Journal of Chengdu University of Traditional Chinese Medicine;2006-03
4 WU Jun-mei,PU Yi,XUE Hong,et al(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China);Inhibitory Effect of Acupuncture Acting on the Provocation of Heroin Euphoria Memory Trace[J];Journal of Chengdu University of Traditional Chinese Medicine;2006-04
5 LIU Jian, XIA Lun Zhu, FENG Yi Rong, GAO Jia Rong, LIU Xin Ping, CHEN Hao (The First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei 230038);The influence on xinfeng capsule on the apoptosis of the synoviocyte and thymus-lymphocyte of adjurant arthritis rat by annexin V/PI[J];Anhui Medical and Pharmaceutical Journal;2004-01
6 YANG Shi You, HUANG Shi Fu,SUN Bei,TIAN Jun (Anhui Institute of Pharmacy,Hefei 230022 );Effect of beishao jieyu granules in depression model mice[J];Anhui Medical and Pharmaceutical Journal;2004-02
7 Liu Zhongqi,Hu Yongfang (Department of Otorhinolaryngology,The First Affiliated Hospital of Lanzhou Medical College, Gansu Lanzhou 730000;A simple method for determination of malondialdehyde[J];Journal of Gansu College of Traditional Chinese Medicine;2001-03
8 Chen Shaoqiang , Huang Yan, Chen Ruihua, Zhang Geng (Department of Anatomy, Fujian Medical University, Fuzhou 350004, China);EFFECT OF TREATMENT WITH TETROMETHYLPRAGINE AND AMINOGUANIDINE ON VEGF IN THE RETINA OF DIABETIC RATS[J];Chinese Journal of Histochemistry and Cytochemistry;2002-03
9 Chen Mingjia~*,Wu Yichun,Wu Qiang,Yang Yan, Yang Feng, Chen Minzhu(Anhui Medical College, Hefei, Anhui,230061,China; ~1Anhui Medical University, Hefei 230032,China) \;;EFFECT OF LIVER-AID TABLETS ON NF-κB EXPRESSION IN RAT HEPATIC FIBROSIS[J];Chinese Journal of Histochemistry and Cytochemistry;2005-04
10 Huang Weiwei, Ye Duyun 1, Bai Ming, Ye Shiqiao 1, Wuping 1 (Department of Internal Medicine, The Affiliated Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077; 1Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China);EXTRACTION OF DNA BINDING PROTEINS FROM THE SARCOPLASMIC RETICULUM OF RAT DIAPHRAGM AND THEIR ASSOCIATION WITH DIAPHRAGM FUNCTION[J];Chinese Journal of Histochemistry and Cytochemistry;2002-04
China Proceedings of conference Full-text Database 5 Hits
1 WANG-Gang~1 LIU-Bin~1 QI-Bin~2 CHEN-Huaqiong~1 DU Biao~3 (1.Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China, 2.Shiyan Maternal and Child health Hospital,Shiyan 442001; 3 Dept.of pharmacy,Hospital Chong qing sanxia chong qing 404000);Experiment study on antihepatic fibrosis effect of chai-hu and ge-gen in wistar mice[A];[C];2007
2 Xu Fangming Guoyi~1 Chen Shuangbai~1 (Biomedical engineering department of Chongqi university if medical science,Chongqi,400016; Tianjin college of traditional Chinise medicine,Tianjin,300193);Effects of dadun with acupuncture on metabolizability of energy in Acute Hypoxia Mice[A];[C];2005
3 Zhang Li Wangjin Guo Guo-Zhen Department of Radiation Medicine,Faculty of preventive Medicine,The Fourth Military Medical University.Xian 710032,China;Effects of EMP exposure on the memory function of rat pups[A];[C];2007
4 ;Experimental Study on anti-anxiety effects and mechanism in mmice of Shu Dihuang[A];[C];2006
5 Lai Xiao-ping, Chen Jian-nan, Ye Mu-rong, Hou Shao-zhen, Li Geng- (Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405 );The therapeutic Effect of Isodon lophanthoides var.gerardianus (Benth.) H.Hara on liver-injured animal models[A];[C];2006
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIU Jing-jing,CHEN Quan-zhen,ZENG Jiang-ning,GAO Ai-gen,LIAO Yi-bo(Second Institute of Oceanography,SOA,Laboratory of Marine Ecosystem and Biogeochemistry,SOA,Hangzhou 310012,China);Advances in the research of bioactive substances from marine microorganisms[J];Journal of Marine Sciences;2007-01
2 AI Feng,XU Qiang-zhi,YANG Yu,LIU Xiao-yu,SHI Xiao-qiong,SONG Zhi-gang,JIAO Bing-hua~*(Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China);Bioactive cyclodipeptides extracted from marine microbes in East China Sea[J];Academic Journal of Second Military Medical University;2006-01
3 ZHANG Hai-long 1,TIAN Li 2,HUA Hui-ming 1,PEI Yue-hu 1 (1. School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016 ,China;2. First Institute of Oceanography,State Oceanic Administration,Qingdao 266003,China);Studies on the chemical constituents from the mycelia of marine fungus Aspergillus versicolor[J];Chinese Journal of Marine Drugs;2004-05
4 CHEN Guang-ying~(1,3),ZHU Feng~2,LIN Yong-cheng~3,Vrijmoed L L P~4(1.Key Lab of Tropical Medicinal Plant Chemistry of Hainan Province,Department of Chemistry,Hainan Normal University,Haikou 571158,China;2.Department of Chemistry & Chemical Engineering,Foshan University,Foshan 528000,China;3.School of Chemistry & Chemical Engineering,Zhongshan University,Guangzhou 510275,China;4.Department of Biology & Chemistry,City University of Hongkong,Hongkong,China);Secondary metabolites of a mangrove endophytic fungus(No.1947)from the South China Sea[J];Chemical Research and Application;2007-01
5 LI Dong1, ZHU Wei-ming 1, GU Qian-qun 1, CUI Cheng-bin1, 2, ZHU Tian-jiao 1, LIU Hong-bing 1, FANG Yu-chun 1 (1. Key Laboratory of Marine Drugs of MEC & SP, Ocean University of China, Qingdao 266003, China; 2. Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China);Structural identification and anti-tumor activity of Diketopi-perazines from secondary metabolites of marine-derived actinomycete H2003[J];Marine Sciences;2007-05
6 LIU Hai-bin1,GAO Hao1,WANG Nai-li2,LIN Hai-peng3,HONG Kui3,YAO Xin-sheng1(1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Key Lab.for New Drugs Research of TCM.Shenzhen 518055,China;3.Institute Tropical Biosciences and Biotechnology,Haikou 571101,China);Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007)[J];Journal of Shenyang Pharmaceutical University;2007-08
7 SUN Yi1,L A-li1,TIAN Li2,WEI Lan3,PEI Yue-hu1 (1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Department of Biological Pharmacy,Qingdao University of Science and Technology,Qingdao 266042,China;3.School of pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Secondary metabolism product of fungus Trichoderma reesei[J];Journal of Shenyang Pharmaceutical University;2007-09
8 ZHANG Wen, GUO Yue-Wei* State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;Research eevelopment on chemically defensive substances of opisthobranch molluscs[J];Acta Ecologica Sinica;2007-03
9 ZHANG Ping(College of Life Science,Hunan Normal University,Changsha,410081,Hunan,China);Advances on cordyceps genus fungi research[J];Journal of Biology;2003-06
10 GU Jing-Yan1, LIU Hong-Bing1, CUI Cheng-Bin 1,2 , GU Qian-Qun1(1. Key Laboratory of Marine Drugs, Ministry of Education, China; Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, China; 2. Beijing Institute of Toxicology and Pharmacology, AMMS, Beijing 10085, China);Isolation and Identification of Cyclic Dipeptides from a Marine-DerivedStreptomyces albogriseolus[J];Journal of Ocean University of Qingdao;2005-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved