Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chemical Research and Application》 2008-03
Add to Favorite Get Latest Update

Determination of conversion and enantiomeric excess during chiral synthesis or resolution by HPLC with polarimetric detector

LEI Qiang ,SHEN Chen-jian,XIE Yong-mei, , DU Ting-ting, FU Chao, SONG Hang (Department of Pharmaceutical and Biological Engineering, Sichuan University, Chengdu 610065,China)  
Determining the change of enantiomeric excess is very important to confirm the reaction termination in the chiral synthesis or enantiomer resolution. The change of conversion and enantionmeric excess in the synthesis or resolution can be determined by HPLC with online polarimeter. Using this method,the optimum results are obtained in the synthesis of D-(-)-phenylglycine butyl ester hydrochloride which is used for resolving mandlic acid and the porcine pancertic lipase-catalyzed transesterification.
【CateGory Index】: O657.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhang Xin, Gao Lianxun * (Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022);The Research of Cellulose Derivatives as Chiral Stationary Phases and High Performance Liquid Chromatography with Polarimeter as On-line Detector[J];Chinese Journal of Analytieal Chemistry;2001-05
2 ZANG Jian, WANG Zhi-jun, WU Yi-zu(Nanjing University of Technology, Jiangsu 210009,China);The Optical Resolution of Mandelic Acid[J];Fine Chemical Intermediates;2005-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LEI Li-li et al (College of Biological Science and Technology,Yangzhou University,Yangzhou,Jiangsu 225009);GC-MS Analysis on the Components of Fatty Acids in the Muscle of Anak Chicken[J];Journal of Anhui Agricultural Sciences;2009-13
2 PENG Mei et al(College of Plant Protection,Anhui Agricultural University,Hefei,Anhui 230036);Research Progress on the Residue Analytical Method in Fluroxypyr[J];Journal of Anhui Agricultural Sciences;2009-13
3 FENG Hui 1 ,XU Yan-ping 1 ,MEI Li-hua 1 ,ZHAO Zhi-de 2 , ZHANG Yong-feng 2 , ZHANG Yan 2 , LUO Jie 2 (1.Anhui Center for Disease Control and Prevention,Hefei Anhui,230061,China;2.College of Public Health,Anhui Medical University,Hefei Anhui,230032,China);Application and Research of Dualwavelength Monitoring Qualitative Technology in Testing Additives of Food[J];Anhui Journal of Preventive Medicine;2005-04
4 FENG Hui,XIE Ji-an,MEI Li-hua(Anhui Center for Disease Control and Prevention,Hefei Anhui,230061,China);Experimental Research on Rapid Test for Sudan 1 in Chili Powder with HPLC[J];Anhui Journal of Prevent Medicine;2006-02
5 FENG Hui,MEI Li-Hua,XIE Ji-an(Anhui Provincial Center for Disease Control and Prevention,Hefei Anhui,230061,China);Research on New Technologies for Qualitative and Quantitative Test of Artificial Synthetic Colorants in Food by HPLC[J];Anhui Journal of Preventive Medicine;2008-03
6 WU Ai-Chun~① ZHANG Yong-Pu~ ②③ ZHOU Hua-Bin~③(① Yongjia College of Zhejiang Radio and TV University, Wenzhou 325100;② School of Life and Environmental Sciences, Wenzhou University, Wenzhou 325027;③ Research Institute of Biological Resource and Biodiversity, Wenzhou University, Wenzhou 325027, China);Analysis and Evaluation of the Nutritive Components in the Edible Part of Estellarca olivacea[J];Chinese Journal of Zoology;2009-01
7 WANG Dan-li,XU Shan-liang,XU Ji-lin,ZHAO Zhi-yun(College of Life Science and Biological Engineering,Ningbo University,Ningbo 315211,China);Comparisons of Fatty Acid Composition in Daphnia Pulex in Different Culture Media[J];Fisheries Science;2005-09
8 ZHENG Yan-zhi,WANG Fei (Guangzhou Tinci High-Tech Materials Co.,Ltd,Guangzhou 510760,China);Extraction and determination of residual acrylamide monomer[J];China Surfactant Detergent & Cosmetics;2007-06
9 LIU Hongqiang,HE Yan,JIN Huixia (Henan Urban Construction College,Pingdingshan 467001,China);HPLC analysis of benzene in industrial waste water[J];Journal of Henan Urban Construction Junior College;2002-01
10 JIANG He ZENG Wen - bi (Chongqing University of Science and Technology, Chongqing 400050);Study on Liquid Chromatograph[J];Journal of Chongqing Polytechnic College;2005-01
China Proceedings of conference Full-text Database 4 Hits
1 ZHANG Xin ZHANG Yu-lin LIU Guo-song(1.School of Control Science and Engineering,Shandong University,Jinan 250061,China;2.School of Management,Tianjin University,Tianjin 300072,China);Circuit design for the micro-current signal in amperometric detection[A];[C];2005
2 Fa Yang Xu Xu Lei Xiaoling(Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, China);Signal-to-noise is an Important Index for UV Detector in HPLC Instrument[A];[C];2005
3 HUA Jie, XU Sheng-ming, ZHANG Qing, XU Jing-ming (Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China; Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000, China; Department of Environmental Science and Technology, Tsinghua University, Beijing 100084, China);Preparation of polymerized rosin and quantitative analysis of its dimers[A];[C];2005
4 YUAN Xiao-chao,TAO Chang-yuan,LIU Zuo-hua,ZHOU Bin,DU Jun~* and SUN Da-gui(College of Chemistry & Chemical Engineering,Chongqing University,Chongqing 400044);GC analysis of products from methanol liquid phase carbonylation to acetic acid[A];[C];2009
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved