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《Chemical Research and Application》 2009-11
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Property and mechanism study of hesperidin imprinted polymer

ZHU Xiu-fang,HE Guang-yan,CHENG Hui-ling,YANG Xue-qiong,CAO Qiu-E,DING Zhong-tao(Key Laboratory of Medicinal Chemistry for Nature Resource,Ministry of Education,School ofChemical Science and Technology,Yunnan University,Kunming 650091,China)  
In order to prepare a novel adsorption material selective to hesperidin(HES),a HES imprinted polymer(MIP) was prepared in methanol with HES as template molecule,acryl amide(AM) as functional monomer,ethylene glycol dimethacrylate(EDMA) as cross-linker.Its adsorption property and selectivity were evaluated by equilibrium adsorption experiment method.The mechanism in imprinting system and recognition progress were explored.The obtained results revealed appriapriate affinity and selectivity of HES-MIP to HES.In 0.04 mol / L HES methanol solution,the distribution coefficients KD of HES on MIP and corresponding NMIP are 10.17 and 2.973,respectively.The imprinting factor α is 3.421.Comprard to the analogues of Rutin and narigin,the corresponding selectivity factor β reached 2.446 and 1.446.The MIP was furthermore used in complex sample and analyzed by high efficiency liquid phase chromatography.The results were pleased which indicated a possibility of being separation and enrichment material.
【Key Words】： molecularly imprinted polymer hesperidin molecular recognition mechanism
【Fund】： 教育部新世纪优秀人才支持计划(NCET-08-0925)资助项目;; 云南省自然科学基金(2006B0002Q)资助项目;; 云南大学校基金(2005Q003A)资助
【CateGory Index】： O631.3
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