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《Chemical Research and Application》 2016-05
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Study on the interaction between noradrenaline bitartrate and bovine serum abumin

ZHANG Xue-jiao;QI Shu-hua;LIU Chun-ye;ZHAO Xiao-li;Department of Applied Chemistry,School of science,Northwestern Polytechnical University;Department of Pharmacy,Xi'an Medical University;  
The interaction between noradrenaline bitartrate( NE-B) and bovine serum albumin( BSA) was studied by ultraviolet and affinity capillary electrophoresis in this paper.As shown by the results of ultraviolet,ultraviolet of BSA is increasing with the increase of NE-B content because of the formation of BSA-NE-B complex.It was shown by the results of affinity capillary electrophoresis that The interacted constant is different at different temperatures.The interacted constant of them was 1.03×10~4L·mol~(-1)and 9.14 ×10~3L·mol~(-1)at 37℃ and 25℃,respectively.From thermodynamic coordination it can be judged that the binding of NE-B and BSA is a spontaneous process.And the binding power between NE-B and BSA is hydrophobic power.
【Fund】: 国家自然科学基金项目(81202492)资助;; 陕西省科技厅项目(2014K02-11-01)资助
【CateGory Index】: O657;R969.2
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