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Chen Fener;Yu Hongxia;Wuan Jiangling; Zhang Hong;Feng Xiumei; Bie Liliang(Laboratory of Synthetic Drugs,Wuhan Institute of Chemical Technology,Hubei 430074)  
Dichlordenzaldehyde treated with methyl acetoacetate via Knoevenagel -Doebner con-densation in the presena of anhydrous ZnCl_2 to give methyl 2,3-dichlorobenzylidene acetoacetate(2),which reacted with ethyl 3-aminocrotonate in the presence of cation exchange resin D 61 bycyclising Michael addition tO afford felodipine. The total yield was 76.5% based on 2,3-dicniorobenzaldehyde, The effect of quantity of anhydrous ZnCl_2 and reaction tempcrature on yieldof 2 was investigated. The influene of different cation exchange resins on yield and quality of 1 wasalso observed.The mild reations,convenient work-up and higer purity of the productwere the advantages of this process.
【CateGory Index】: TQ463.54
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