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《CHEMICAL RESEARCH AND APPLICATION》 1995-02
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STUDY ON SYNTHESIS FOR THE CALCIUM ANTAGONTST ⅢSYNTHESIS OF FELODIPINE

Chen Fener;Yu Hongxia;Wuan Jiangling; Zhang Hong;Feng Xiumei; Bie Liliang(Laboratory of Synthetic Drugs,Wuhan Institute of Chemical Technology,Hubei 430074)  
Dichlordenzaldehyde treated with methyl acetoacetate via Knoevenagel -Doebner con-densation in the presena of anhydrous ZnCl_2 to give methyl 2,3-dichlorobenzylidene acetoacetate(2),which reacted with ethyl 3-aminocrotonate in the presence of cation exchange resin D 61 bycyclising Michael addition tO afford felodipine. The total yield was 76.5% based on 2,3-dicniorobenzaldehyde, The effect of quantity of anhydrous ZnCl_2 and reaction tempcrature on yieldof 2 was investigated. The influene of different cation exchange resins on yield and quality of 1 wasalso observed.The mild reations,convenient work-up and higer purity of the productwere the advantages of this process.
【CateGory Index】: TQ463.54
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【References】
Chinese Journal Full-text Database 1 Hits
1 Cheng Huiyao (Chongqing Institute for Drag Control, Chongqing, China 401121);Determination of Organic Solvent Residual Volume in Felodipine Raw Material by Headspace Gas Chromatography[J];China Pharmaceuticals;2006-19
【Citations】
Chinese Journal Full-text Database 1 Hits
1 $$$$XU Yun-Gen;HUA Wei-Yi(Division of Medicinal Chemistry,China Pharmaceutical University;Nanjing 210009);SYNTHESIS OF 2,3-DICHLOROBENZALDEHYDE[J];CHINESE JOURNAL OF PHARMACEUTICALS;1994-08
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 Wang Dimin;STUDIES ON SYNTHESIS OF TEREPHTHALALDEHYDE[J];;1999-01
2 Zhao Hongbin Liu Zhigang Lin Yuanbin Yi Bin Zhou Ning(College of Chemistry and Chemical Engineering, Xiangtan Universty, Xiangtan, 411105);A Study on a Novel Method for Synthesizing Terephthalaldehyde[J];Dyestuff Industry;2001-01
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4 ZHANG Yue,LIU Jian-wu,YAN Sheng-hu,SHEN Jie-fa(Institute of Design and Research,Jiangsu Polytechnic University,Changzhou 213164,China);Study of Synthesis of 3,4-Dimethylbenzaldehyde with Formylation Method[J];Journal of Jiangsu Polytechnic University;2007-01
5 Cheng Huiyao (Chongqing Institute for Drag Control, Chongqing, China 401121);Determination of Organic Solvent Residual Volume in Felodipine Raw Material by Headspace Gas Chromatography[J];China Pharmaceuticals;2006-19
6 DENG Hong,CHEN Hong-Biao,LIN Yuan-Bin*,LIU Fei-Meng (College of Chemistry, University of Xiangtan, Xiangtan 411105);Synthesis of 2,3-Dichlorotoluene[J];Chinese Journal of Pharmaceuticals;2003-01
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Chinese Journal Full-text Database 10 Hits
1 Luo Wenbo ,Zhang SanqiDepartment of Chemistry , Xi’an 710033;Improved method for synthesis of 1, 4-dihydropridine calcium antag-onists with ultrsound[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1995-01
2 WANG Ming-liang,WU Mei-hong,WU Wei-bing(Department of Chemistry and Chemical Engineering,Southeast University,Nanjing 210096,China);Synthesis and Fluorescent Property of 4-Tetrahydroquinolone[J];Chinese Journal of Luminescence;2006-03
3 ZHAO Bing Jun, ZHU Xiao Qing, HE Jia Qi, XIA Chi Zhong , CHENG Jin Pei  (Department of Chemistry, Nankai University, Tianjin 300071, China; Department of Chemistry, Shanxi University , Taiyuan 030006, China);An Investigation on Synthesis and Spectroscopic Properties of Hantzsch Type 1,4 Dihydropyridine Derivatives[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;1999-11
4 FU Nan-Yan, YUAN Yao-Feng, PANG Mei-Li, WANG Ji-Tao *(Department of Chemistry, Nankai University, Tianjin 300071, China);A Novel One-pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones Catalyzed by Indium Tribromide[J];Chemical Research In Chinese Universities;2003-01
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6 HU Liang,HUANG Pei-chi(Xuzhou Medicine Vocational College,Xuzhou 221116,China);Synthesis of 5-Methyl-1-Aryl-1,2,3-Triazole Derivatives[J];Technology & Development of Chemical Industry;2006-10
7 ZHOU Jin-kang,YU Yue-dong (Chemistry Department, Guizhou Education College, Guiyang,Guizhou 550003, China);Synthesis of 1,4-dihydropyridine compound[J];Journal of Guizhou Educational College;2005-02
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9 WU Jian-yi~1, JIN Ji-chun~2, HUANG Xiao-yang~1 (1. Department of Chemical Engineering Jiaxing College, Jiaxing 314001, China; 2. Department Practical Chemical, Huadong Sceince University, Shanghai 200002, China);Synthesis of Diethyl 3,5-Pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-diethyl[J];Chinese Journal of Synthetic Chemistry;2001-01
10 WANG Jian-ping 1, DU Mei-ju2, FU Yong-ju3,WANG Jian-ge1, LI Ning1, ZHENG Ai-xia1(1. Department of Chemistry, Luoyang Normal University, Luoyang 471022, China; 2. Department of Chemistry, Shangqiu Normal University, Shangqiu 476000, China; 3. College of Chemical Engineering & Pharmaceutics, Henan University of Science and Technology, Luoyang 471003, China);Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives[J];Chinese Journal of Synthetic Chemistry;2007-01
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