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《Journal of Sichuan University (Medical Sciences Edition)》 1988-03
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ANTIHYPERCHOLESTEROLEMIC AND ANTISTEATOTIC EFFECT OF KONJAC-POLYSACCHARIDE IN RATS FED HIGH CHOLESTEROL DIET

Zhang Yinzhu;Zheng Zhiren;Yang Chaoying;Dong Haiou;Liao Guoyang Department of Pathology Hou Yunhua;Zhang Lishi Department of Nutrition and Food Hygiene  
The paper reports a study of the anti-hypercholesterolemic and antisteatotic ef-fects of konjac-polysaccharide. The Konnya-ku powder(KP)used was natively producedand refined from the tubers of Amor-phophallus konjac K Koch, and contained84.8% of glucomannan. One hundred andtwenty Sprague-Dawley rats were dividedinto 5 groups: a basal diet group, a highcholesterol diet group and 3 test groupsfed a diet similar to that of the high chol-esterol diet group with addition of KP ata dosage of 2. 5%, 5%, or 10%, respectively.Eight animals of each group were killedat 4, 8, 12 weeks after the treatment. Theresults showed that KP could markedlylower the cholesterol levels in the seraand in the livers of rats fed high choles-terol diets. At the end of the 4th week,the serum cholesterol levels of the 5% andthe 10% KP groups and the liver cho-lesterol levels of the 10% KP group wereshown to be lowered more significantlythan those of the high cholesterol dietgroup. At the end of the 12th week, serumcholesterol levels of all the three KP groupswere found to be lowered to the normallevel, and so did the liver cholesterol levelof the 10% KP group. Steatotic effect ofKP was also confirmed by the histopatho-logic examination of the livers. Fattydegeneration of the livers of all the 3 KPgroups was found to be ameliorated invarying degrees, and at the end of the12th week, no significant difference wasnoticed between the basal and the 5%,10% KP groups.
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