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《Journal of West China University of Medical Sciences》 2001-03
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Protective Effect of Berberine on Isolated Perfused Heart in Heart Failure

Zhou Zuyu, Xu Jianguo, Lan Tingjian.Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China  
Objective To examine the protective action of berberine against the development of heart failure. Methods Wister rats were divided into two groups. The Langendorff perfusion of isolated heart was performed and Verapamil was used to bring about acute heart failure. The experiment group was given berberine (10 -6 mol/L) before the use of Verapamil, but the control group was not given the berberine. A comparison was made on the degree of heart failure between the two group.Results The degree of heart failure in the experiment group was significantly less severe than that in the control group ( P 0.001). Conclusion Berberine has the protective action against to the development of heart failure.
【Fund】: 四川省科委科研基金资助 (批准号 970 14 )
【CateGory Index】: R541.61
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